G4401

Guanosine 5′-diphospho-β-L-fucose sodium salt

Name: Guanosine 5′-diphospho-β-<SC>L</SC>-fucose sodium salt
Brand: SIGMA

≥85%, powder

Synonym(s):

6-Deoxy-β-L-galactopyranosylguanosine 5′-diphosphate, GDP-Fuc, GDP-fucose

Select a Size

All Photos(1)

About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₃N₅Na₂O₁₅P₂

CAS Number:

15839-70-0

Molecular Weight:

633.31

UNSPSC Code:

12352204

PubChem Substance ID:

24895171

NACRES:

NA.32

MDL number:

MFCD00058553

Product Name

Guanosine 5′-diphospho-β-L-fucose sodium salt, ≥85%

SMILES string

CC1OC(OP(O)(=O)OP(O)(=O)OCC2OC(C(O)C2O)n3cnc4C(=O)N=C(N)Nc34)C(O)C(O)C1O

InChI

1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)

InChI key

LQEBEXMHBLQMDB-UHFFFAOYSA-N

assay

≥85%

form

powder

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

Quality Level

100

Looking for similar products? Visit Product Comparison Guide

Application

Guanosine 5′-diphospho-β-L-fucose sodium salt may be used as a component of fucosyltransferase VII (FTVII) reaction buffer to aid exofucosylation in murine adipose tissue-derived mesenchymal stromal cells (AMSCs). It has been used for microbe agglutination assay and agglutination inhibition assay.

Guanosine 5′-diphospho-β-L-fucose sodium salt has been used for microbe agglutination assay and agglutination inhibition assay.

General description

Guanosine 5′-diphospho-β-L-fucose (GDP-fucose) is a sugar nucleotide present in bacteria and humans and is a fucosyltransferase substrate.

Substrate for fucosyltransferase

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Revisiting the substrate specificity of mammalian α1,6-fucosyltransferase reveals that it catalyzes core fucosylation of

Qiang Yang et al.

The Journal of biological chemistry, 292(36), 14796-14803 (2017-07-22)

The mammalian α1,6-fucosyltransferase (FUT8) catalyzes the core fucosylation of

Mechanism and active site residues of GDP-fucose synthase.

Stephen T B Lau et al.

Journal of the American Chemical Society, 130(51), 17593-17602 (2008-12-05)

L-fucose, 6-deoxy-L-galactose, is a key component of many important glycoconjugates including the blood group antigens and the Lewis(X) ligands. The biosynthesis of GDP-L-fucose begins with the action of a dehydratase that converts GDP-D-mannose into GDP-4-keto-6-deoxy-mannose. The enzyme GDP-fucose synthase, GFS

Structural insights into the mechanism of protein O-fucosylation.

Erandi Lira-Navarrete et al.

PloS one, 6(9), e25365-e25365 (2011-10-04)

Protein O-fucosylation is an essential post-translational modification, involved in the folding of target proteins and in the role of these target proteins during embryonic development and adult tissue homeostasis, among other things. Two different enzymes are responsible for this modification

Antibody glycoengineering strategies in mammalian cells.

Qiong Wang et al.

Biotechnology and bioengineering, 115(6), 1378-1393 (2018-02-20)

As a key parameter impacting functional and structural heterogeneity, protein glycosylation is a critical quality attribute for antibody biotherapeutic manufacturing. The glycan patterns on recombinant antibodies, particularly on the conserved fragment crystallizable (Fc) region, can have significant effects on an

Histo-blood group antigen-binding specificities of human rotaviruses are associated with gastroenteritis but not with in vitro infection.

Laure Barbé et al.

Scientific reports, 8(1), 12961-12961 (2018-08-30)

Human strains of rotavirus A (RVAs) recognize fucosylated glycans belonging to histo-blood group antigens (HBGAs) through their spike protein VP8*. Lack of these ligands due to genetic polymorphisms is associated with resistance to gastroenteritis caused by P[8] genotype RVAs. With

View All Related Papers