G4626

L-Glutathione oxidized disodium salt

Name: <SC>L</SC>-Glutathione oxidized disodium salt
Brand: SIGMA

≥98%, suitable for HPLC

Synonym(s):

GSSG

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₃₀N₆Na₂O₁₂S₂

CAS Number:

103239-24-3

Molecular Weight:

656.59

MDL number:

MFCD00148894

UNSPSC Code:

12352209

PubChem Substance ID:

24895179

NACRES:

NA.26

Beilstein/REAXYS Number:

6265389

Product Name

L-Glutathione oxidized disodium salt, ≥98%, powder

SMILES string

[Na+].[Na+].N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C([O-])=O)C(=O)NCC(O)=O)C(=O)NCC([O-])=O)C(O)=O

InChI

1S/C20H32N6O12S2.2Na/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38;;/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38);;/q;2*+1/p-2/t9-,10-,11-,12-;;/m0../s1

InChI key

DRFILBXQKYDTFW-JIWRMXRASA-L

assay

≥98%

form

powder

technique(s)

HPLC: suitable

impurities

ethanol, essentially free

color

white to off-white

storage temp.

−20°C

Quality Level

200

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Related Categories

Amino Acids

Biochemicals

Cell Culture Supplements & Reagents

Application

L-Glutathione oxidized disodium salt has been used in 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB)/glutathione reductase enzyme recycling method to determine plasma or tissue glutathione levels. It has also been used in NADPH-dependent glutathione disulfide reduction assay.

Biochem/physiol Actions

Oxidized L-glutathione is frequently measured in vivo as an indicator of oxidative stress. Oxidized L-Glutathione may be converted to L-glutathione by various reducing systems.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Methods for the Determination of Plasma or Tissue Glutathione Levels

Trent E, et.al

Methods in Molecular Biology, 889, 315-324 (2012)

Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

Sofi Eriksson

Nature Communications (2015)

Oxidized forms of glutathione in peripheral blood as biomarkers of oxidative stress.

Rossi R

Clinical Chemistry, 52(7), 1406-1414 (2006)

Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat.

S K Tandon et al.

Toxicology letters, 145(3), 211-217 (2003-10-29)

The influence of an antioxidant agent such as N-acetyl cysteine (NAC) or mannitol on the cadmium chelating ability of monoisoamyl 2,3-dimercaptosuccinate (MiADMS) was investigated in cadmium pre-exposed rats. This ester of 2,3-dimercaptosuccinic acid (DMSA), an accepted drug for lead poisoning

Comparative physiological, metabolomic, and transcriptomic analyses reveal mechanisms of improved abiotic stress resistance in bermudagrass [Cynodon dactylon (L). Pers.] by exogenous melatonin.

Haitao Shi et al.

Journal of experimental botany, 66(3), 681-694 (2014-09-17)

Melatonin (N-acetyl-5-methoxytryptamine), a well-known animal hormone, is also involved in plant development and abiotic stress responses. In this study, it is shown that exogenous application of melatonin conferred improved salt, drought, and cold stress resistances in bermudagrass. Moreover, exogenous melatonin

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