H2775
DL-threo-β-Hydroxyaspartic acid
Synonym(s):
threo-2-Amino-3-hydroxysuccinic acid
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About This Item
Empirical Formula (Hill Notation):
C4H7NO5
CAS Number:
Molecular Weight:
149.10
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352106
NACRES:
NA.32
EC Number:
224-299-4
MDL number:
InChI key
YYLQUHNPNCGKJQ-JCYAYHJZSA-N
InChI
1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m1/s1
SMILES string
N[C@H]([C@@H](O)C(O)=O)C(O)=O
storage temp.
−20°C
Quality Level
Gene Information
human ... GLUL(2752)
mouse ... GLUL(14645)
General description
DL-threo-β-hydroxyaspartic acid (THA) is a glutamate uptake inhibitor.
Application
DL-threo-β-Hydroxyaspartic acid (THA) has been used to block glutamate transport in cannulated sprague dawley rat.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Richelle A Hemendinger et al.
Neurotoxicity research, 13(1), 49-61 (2008-03-28)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting from the progressive loss of motor neurons in the spinal cord and brain. To date, clinically effective neuroprotective agents have not been available. The current study demonstrates for the first time
Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid.
Matthias Strieker et al.
Chembiochem : a European journal of chemical biology, 9(3), 374-376 (2008-01-24)
Francis J Castellino et al.
Methods in molecular biology (Clifton, N.J.), 446, 85-94 (2008-04-01)
Vitamin K-dependent coagulation plasma proteins possess from 9-12 residues of gamma-carboxyglutamic acid (Gla) distributed over a ca. 45 amino acid peptide sequence, i.e., the Gla domain, which encompasses the NH2-terminal region. In addition, epidermal growth factor (EGF) homology units present
Z Kawakami et al.
Neuroscience, 159(4), 1397-1407 (2009-05-05)
To clarify the mechanism of yokukansan (TJ-54), a traditional Japanese medicine, against glutamate-mediated excitotoxicity, the effects of TJ-54 on glutamate uptake function were first examined using cultured rat cortical astrocytes. Under thiamine-deficient conditions, the uptake of glutamate into astrocytes, and
Yasuhiro Kosuge et al.
Neuroscience letters, 454(2), 165-169 (2009-05-12)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by selective loss of motor neurons. Although organotypic spinal slice cultures (OSCs) exposed to inhibitors of glutamate uptake have been used as a model of ALS for screening of potentially
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