Skip to Content
Merck

I7016

H-7 dihydrochloride

≥98% (HPLC)

Synonym(s):

1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride, Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C14H17N3O2S · 2HCl
CAS Number:
108930-17-2
Molecular Weight:
364.29
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
24278496
MDL number:
MFCD00036961
Beilstein/REAXYS Number:
5840763

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI

1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H

SMILES string

Cl.Cl.CC1CNCCN1S(=O)(=O)c2cccc3cnccc23

InChI key

OARGPFMFRLLKPF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

solubility

H2O: 20 mg/mL

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584)

Related Categories

General description

H-7 dihydrochloride blocks human immunodeficiency virus (HIV-1) replication in MOLT-4 (clone No. 8) cell line. It increases the secretion of interleukin 1β (IL-1β).

Application

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

Biochem/physiol Actions

Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.

Disclaimer

Light sensitive

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
021K5012
118H5159
105H5805
079H5001
073H5875

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Molecular diversity of cell-matrix adhesions
Zamir E, et al.
Journal of Cell Science, 112(11), 1655-1669 (1999)
Endotoxin in Health and Disease, 289-298 (1999)
A new dimension in retrograde flow: centripetal movement of engulfed particles
Caspi A, et al.
Biophysical Journal, 81(4), 1990-2000 (2001)
Mechanism of inhibitory effect of glycyrrhizin on replication of human immunodeficiency virus (HIV)
Ito M, et al.
Antiviral Research, 10(6), 289-298 (1988)
Christopher J Groten et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(6), 2747-2765 (2015-02-13)
It is unknown whether neurons can dynamically control the capacity for secretion by promptly changing the number of plasma membrane voltage-gated Ca(2+) channels. To address this, we studied peptide release from the bag cell neurons of Aplysia californica, which initiate

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service