L7022
Sodium L-lactate
~98%
Synonym(s):
(S)-2-Hydroxypropionic acid sodium salt, L-Lactic acid sodium salt, Sarcolactic acid sodium salt
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About This Item
Empirical Formula (Hill Notation):
C3H5NaO3
CAS Number:
Molecular Weight:
112.06
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
EC Number:
212-762-3
Beilstein/REAXYS Number:
4567087
MDL number:
Product Name
Sodium L-lactate, ~98%
InChI
1S/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1/t2-;/m0./s1
InChI key
NGSFWBMYFKHRBD-DKWTVANSSA-M
SMILES string
[Na+].C[C@H](O)C([O-])=O
biological source
synthetic (chemical)
assay
~98%
form
powder or crystals
color
white to faint yellow
mp
163-165 °C (lit.)
solubility
water: 50 mg/mL, clear, colorless
storage temp.
2-8°C
Quality Level
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Application
Sodium L-lactate has been used:
- as a medium supplement and cell fuel source for human mammary epithelial cell line(MCF10A) and dendritic cell culture
- as a gluconeogenic substrate in hepatic glucose production assay in primary hepatocytes
- in the glucose production medium for glucose production assay in human embryonic kidney (HEK293T) cells
- as a standard for calibration in lactate assay in bone marrow-derived macrophages
Biochem/physiol Actions
L-lactate is produced from pyruvate by the enzyme lactate dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells.
Features and Benefits
Versatile and adaptable for a wide variety of laboratory and research applications
General description
Sodium L-lactate, an organic acid derived from L-lactic acid, naturally occurs in the body, contributing to pH regulation, acid-base equilibrium, and various physiological processes, including energy metabolism through the Cori cycle. Its versatile properties extend to antimicrobial action by creating an acidic environment that inhibits harmful bacterial growth. In metabolic pathways, Sodium L-lactate exhibits efficient conversion for energy production, potentially surpassing glucose uptake in certain instances, utilizing fatty acids as an alternative fuel source, and stimulating mitochondria for enhanced ATP production, indicating a role in optimizing cellular energy efficiency. Moreover, research suggests neuroprotective capabilities, safeguarding neuronal cells from high-fat diet-induced death and addressing potential links to obesity-related neurodegenerative issues.
This multifaceted nature of Sodium L-lactate positions it as a valuable molecule for research in cellular metabolism, neuroprotection, antimicrobial, and nutritional science, where its diverse properties, including efficient energy conversion, neuroprotective effects, and potent antimicrobial activity contribute to a deeper understanding across these scientific domains.
This multifaceted nature of Sodium L-lactate positions it as a valuable molecule for research in cellular metabolism, neuroprotection, antimicrobial, and nutritional science, where its diverse properties, including efficient energy conversion, neuroprotective effects, and potent antimicrobial activity contribute to a deeper understanding across these scientific domains.
Other Notes
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Lactate is always the end product of glycolysis
Rogatzki MJ, et al.
Frontiers in Neuroscience, 9, 22-22 (2015)
Protein-bound NAD (P) H Lifetime is Sensitive to Multiple Fates of Glucose Carbon
Sharick JT, et al.
Scientific Reports, 8(1), 5456-5456 (2018)
Alternative splicing variant of the scaffold protein APPL1 suppresses hepatic adiponectin signaling and function
Galan-Davila AK, et al.
The Journal of Biological Chemistry, jbc-RA118 (2018)
Dynamic acetylation of phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions
Latorre-Muro P, et al.
Molecular Cell, 71(5), 718-732 (2018)
Latent, Immunosuppressive Nature of Poly (lactic-co-glycolic acid) Microparticles
Allen RP, et al.
ACS biomaterials science & engineering, 4(3), 900-918 (2018)
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