M5693
MEDICA 16
powder, ≥97% (HPLC)
Synonym(s):
3,3,14,14-Tetramethylhexadecanedioic acid
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C20H38O4
CAS Number:
Molecular Weight:
342.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Product Name
MEDICA 16, powder, ≥97% (HPLC)
InChI
1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24)
SMILES string
CC(C)(CCCCCCCCCCC(C)(C)CC(O)=O)CC(O)=O
InChI key
HYSMCRNFENOHJH-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
color
white to beige
mp
154-159 °C
solubility
DMSO: 10 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Related Categories
Biochem/physiol Actions
MEDICA 16 is an ATP-citrate lyase inhibitor and potent triacylglycerol-lowering agent.
MEDICA 16 is an ATP-citrate lyase inhibitor and potent triacylglycerol-lowering agent. The product is hypolipidemic, antidiabetic, and shows reduced adiposity.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
B Kalderon et al.
American journal of physiology. Endocrinology and metabolism, 279(1), E221-E227 (2000-07-14)
Adipose tissue lipolysis and fatty acid reesterification by liver and adipose tissue were investigated in rats fasted for 15 h under basal and calorigenic conditions. The fatty acid flux initiated by adipose fat lipolysis in the fasted rat is mostly
Qi Sun et al.
Molecular pharmacology, 78(5), 804-810 (2010-08-06)
GPR120 is a G protein-coupled receptor expressed preferentially in the intestinal tract and adipose tissue, that has been implicated in mediating free fatty acid-stimulated glucagon-like peptide-1 (GLP-1) secretion. To develop GPR120-specific agonists, a series of compounds (denoted as NCG compounds)
O Hermesh et al.
The Journal of biological chemistry, 273(7), 3937-3942 (1998-03-28)
Mitochondria uncoupling by fatty acids in vivo is still questionable, being confounded by their dual role as substrates for oxidation and as putative genuine uncouplers of oxidative phosphorylation. To dissociate between substrate and the uncoupling activity of fatty acids in
N Mayorek et al.
The Biochemical journal, 289 ( Pt 3), 911-917 (1993-02-01)
Treatment of cholesterol-fed male hamsters kept on a diet of purina chow with beta beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) resulted in a progressive hypocholesterolaemic effect, amounting to a 50% decrease in the cholesterol content of all plasma lipoproteins. The decrease
J C Russell et al.
Diabetes, 47(5), 770-778 (1998-05-20)
The JCR:LA-cp rat develops an extreme obese/insulin-resistant syndrome such that by 12 weeks of age, there is no longer any insulin-mediated glucose turnover. At 4 weeks of age, obese and lean rats have essentially identical basal and insulin-mediated glucose uptake
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service