N4382

Nalidixic acid sodium salt

Name: Nalidixic acid sodium salt
Brand: SIGMA

DNA gyrase inhibitor, powder

Synonym(s):

1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid sodium salt

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All Photos(1)

About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₁N₂NaO₃

CAS Number:

3374-05-8

Molecular Weight:

254.22

NACRES:

NA.77

PubChem Substance ID:

24278589

UNSPSC Code:

12352106

EC Number:

222-159-7

MDL number:

MFCD00064376

Beilstein/REAXYS Number:

3580062

Product Name

Nalidixic acid sodium salt, powder

Quality Level

200

InChI key

ROKRAUFZFDQWLE-UHFFFAOYSA-M

InChI

1S/C12H12N2O3.Na/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;/h4-6H,3H2,1-2H3,(H,16,17);/q;+1/p-1

SMILES string

[Na+].CCN1C=C(C([O-])=O)C(=O)c2ccc(C)nc12

form

powder

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

DNA synthesis | interferes
enzyme | inhibits

originator

Sanofi Aventis

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Nalidixicacid has been used to treat the bacterial cultures to study itsresistance on Salmonella enterica and SalmonellaTyphimurium.

Biochem/physiol Actions

Nalidixic acid sodium salt is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. Inhibits nucleic acid and protein synthesis in Saccharomyces cerevisiae.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Chemical structure: quinolone

Nalidixic acid is a quinolone and can block the activity of bacterial topoisomerase type II enzyme, thereby stopping bacterial replication. It is a potential antibacterial agent against Gram-negative bacteria than Gram-positive bacteria. Nalidixic acid has been studied in the management of urinary tract infections.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H351

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000491339

0000491346

0000480610

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Nalidixic Acid

Acta Entomologica Silesiana, 154-175 (1979)

Impact of a Bacillus Direct-Fed Microbial on Growth Performance, Intestinal Barrier Integrity, Necrotic Enteritis Lesions, and Ileal Microbiota in Broiler Chickens Using a Laboratory Challenge Model.

Daniel Hernandez-Patlan et al.

Frontiers in veterinary science, 6, 108-108 (2019-05-21)

Decreases in the use of antibiotics and anticoccidials in the poultry industry have risen the appearance of necrotic enteritis (NE). The purpose of this study was to evaluate the effect of a Bacillus direct-fed microbial (DFM) on growth performance, intestinal

Quinolone antibiotics.

Thu D M Pham et al.

MedChemComm, 10(10), 1719-1739 (2019-12-06)

The quinolone antibiotics arose in the early 1960s, with the first examples possessing a narrow-spectrum of activity with unfavorable pharmacokinetic properties. Over time, the development of new quinolone antibiotics has led to improved analogues with an expanded spectrum and high

Evaluation of a selected lactic acid bacteria-based probiotic on Salmonella enterica serovar Enteritidis colonization and intestinal permeability in broiler chickens.

Omar F Prado-Rebolledo et al.

Avian pathology : journal of the W.V.P.A, 46(1), 90-94 (2016-08-23)

Two experiments were conducted to evaluate the effect of a lactic acid bacteria-based probiotic (FloraMax-B11®) against Salmonella enterica serovar Enteritidis intestinal colonization and intestinal permeability in broiler chickens. Experiment 1 consisted of two independent trials. In each trial, day-old broiler

Isolation and Identification of Lactic Acid Bacteria Probiotic Culture Candidates for the Treatment of Salmonellaenterica Serovar Enteritidis in Neonatal Turkey Poults.

Margarita A Arreguin-Nava et al.

Animals : an open access journal from MDPI, 9(9) (2019-09-20)

The effect of Lactobacillus spp.-based probiotic candidates on Salmonella enterica serovar Enteritidis (SE) colonization was evaluated in two separate experiments. In each experiment, sixty-one day-of-hatch female turkey poults were obtained from a local hatchery. In both experiments, poults were challenged

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