SML0309

Sodium phenylbutyrate

Name: Sodium phenylbutyrate
Brand: SIGMA

≥98% (HPLC), histone deacetylase inhibitor, powder

Synonym(s):

4-PBA, 4-Phenylbutyric acid, 4-phenylbutyrate, Buphenyl, Sodium 4-phenylbutyrate, TriButyrate

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₁NaO₂

CAS Number:

1716-12-7

Molecular Weight:

186.18

UNSPSC Code:

12352200

PubChem Substance ID:

329825314

NACRES:

NA.77

MDL number:

MFCD00800247

Product Name

Sodium phenylbutyrate, ≥98% (HPLC)

SMILES string

[Na+].[O-]C(=O)CCCc1ccccc1

InChI key

VPZRWNZGLKXFOE-UHFFFAOYSA-M

InChI

1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: ≥5 mg/mL

storage temp.

room temp

Quality Level

100

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Biochem/physiol Actions

Sodium phenylbutyrate is a histone deacetylase inhibitor.

Application

Sodium phenylbutyrate has been used as an endoplasmic reticulum (ER) stress inhibitor to study the role of ER stress in the expression of betatrophin.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

Sodium phenylbutyrate stimulates urinary nitrogen excretion. It is a prodrug, which undergoes β-oxidation to phenylacetate. Sodium phenylbutyrate is used to treat urea cycle disorder. It might be associated with menstrual dysfunction, amenorrhea and painful mucositis of the esophagus and stomach.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000483791

0000440004

0000385496

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Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control

Lee B, et al.

Molecular Genetics and Metabolism, 100(3), 221-228 (2010)

Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies

Lee YH, et al.

Scientific Reports, 6(3), 24013-24013 (2016)

Advances in Clinical Chemistry, Volume 17 (2014)

The Molecular and Genetic Basis of Neurologic and Psychiatric Disease (2008)

TLR2/4-mediated NF-κB pathway combined with the histone modification regulates β-defensins and interleukins expression by sodium phenyl butyrate in porcine intestinal epithelial cells.

Xiujing Dou et al.

Food & nutrition research, 62 (2018-12-24)

Host defense peptides (HDPs) possess direct antibacterial, antineoplastic, and immunomodulatory abilities, playing a vital role in innate immunity. Dietary-regulated HDP holds immense potential as a novel pathway for preventing infection. In this study, we examined the regulation mechanism of HDPs

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