T6069

Thio-TEPA

Name: Thio-TEPA
Brand: SIGMA

Synonym(s):

N,N′,N″-Triethylenethiophosphoramide, Thio-Tep, Thiofozil, Thiotef, Tio-tef, Tiofosfamid, Tiofosyl, Tiofozil, Tris(aziridinyl)phosphine sulfide

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All Photos(2)

About This Item

Empirical Formula (Hill Notation):

C₆H₁₂N₃PS

CAS Number:

52-24-4

Molecular Weight:

189.22

NACRES:

NA.85

PubChem Substance ID:

24900346

UNSPSC Code:

51102829

EC Number:

200-135-7

MDL number:

MFCD00145452

InChI key

FOCVUCIESVLUNU-UHFFFAOYSA-N

InChI

1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

SMILES string

S=P(N1CC1)(N2CC2)N3CC3

form

solid

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

color

white

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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Related Categories

Antibiotics

Biochemicals

Cell Culture Supplements & Reagents

Analysis Note

Solubility - freely soluble in water , in chloroform and in ethanol (96%)

Application

A polyfunctional alkylating agent

Biochem/physiol Actions

The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.

General description

Chemical structure: aziridine

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H350

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

0000340752

0000254894

0000239472

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Magnetic resonance (MR)-derived radiomic features have shown substantial predictive utility in modeling different prognostic factors of glioblastoma and other brain cancers. However, the biological relationship underpinning these predictive models has been largely unstudied, and the generalizability of these models had

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Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 19(1), 117-122 (2012-09-04)

Fifty patients with high-risk hematologic malignancies, underwent an unmanipulated haploidentical bone marrow transplantation (BMT), followed by posttransplantation high-dose cyclophosphamide (PT-CY): the myeloablative (MA) conditioning consisted of thiotepa, busulfan, fludarabine (n = 35), or total body irradiation (TBI), fludarabine (n =

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Annals of oncology : official journal of the European Society for Medical Oncology, 23(10), 2670-2675 (2012-04-05)

High-dose chemotherapy followed by autologous stem-cell transplantation (HCT-ASCT) is a promising approach in eligible patients with primary central nervous system lymphoma (PCNSL). We report long-term data of patients who were treated according to HCT-ASCT containing protocols. We analyzed survival and

Potent inhibition of cytochrome P450 2B6 by sibutramine in human liver microsomes.

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The present study was performed to evaluate the potency and specificity of sibutramine as an inhibitor of the activities of nine human CYP isoforms in liver microsomes. Using a cocktail assay, the effects of sibutramine on specific marker reactions of

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