T9701
TRAIL human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder
Synonym(s):
Apo2 Ligand, Apo2L, TL2, TNF-related apoptosis-inducing ligand
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About This Item
Form:
lyophilized powder
Assay:
≥98% (SDS-PAGE and HPLC)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
19.6 kDa, predicted mol wt ~21 kDa
biological source
human
Quality Level
recombinant
expressed in E. coli
description
extracellular domain
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
mol wt
19.6 kDa, predicted mol wt ~21 kDa
technique(s)
immunofluorescence: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TNFSF10(8743)
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Application
TRAIL human has been used in immunofluorescence analyses, to study the delocalization of melanoma antigen-D2 in the nucleoplasm after a cellular stress.
Human TRAIL can be used as a selection agent for treating human cells for phenotypic enrichments. The product can also be used in chemical transfection for identifying Small RNA Modulators of TRAIL-Induced Apoptosis Pathway by utilizing libraries of synthetic small interfering RNA (siRNA) and microRNAs (miRNA).
Biochem/physiol Actions
TRAIL is a cytokine with anti-inflammatory, and antitumor activity. It is expressed in various cells including immune cells, vascular cells and adipocytes. TRAIL is associated with vascular endothelial cell protection.
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. The product present in both soluble as well as membrane-bound form, can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induce apoptotic cell death in TRAIL-sensitive U343MG cells.
Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.
Physical form
Lyophilized from phosphate buffered saline
Analysis Note
The biological activity is determined by its ability to induce apoptotic cell death in TRAIL-sensitive LN-18 cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Synergistic effect of TRAIL and irradiation in elimination of glioblastoma stem-like cells
Liu J, et al.
Clinical and Experimental Medicine, 1-13 (2018)
Melanoma antigen-D2: a nucleolar protein undergoing delocalization during cell cycle and after cellular stress
Pirlot C, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1863(4), 581-595 (2016)
Jan E Carette et al.
Nature biotechnology, 29(6), 542-546 (2011-05-31)
Insertional mutagenesis in a haploid background can disrupt gene function. We extend our earlier work by using a retroviral gene-trap vector to generate insertions in >98% of the genes expressed in a human cancer cell line that is haploid for
Fatih Birtekocak et al.
Iranian journal of pharmaceutical research : IJPR, 20(2), 45-56 (2021-09-28)
Colon cancer is one of the most prominent causes of cancer-related morbidity and mortality and curable if detected in the early stages. TNF-related apoptosis-inducing ligand (TRAIL) is a therapeutic protein and has a potential anti-cancer activity that is widely used
Lower maternal serum tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) levels in early preeclampsia. A retrospective study
Morano D, et al.
Pregnancy hypertension, 12, 1-5 (2018)
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