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Merck

1604654

USP

Risperidone

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

R 64,766

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About This Item

Empirical Formula (Hill Notation):
C23H27FN4O2
CAS Number:
106266-06-2
Molecular Weight:
410.48
NACRES:
NA.24
PubChem Substance ID:
329751052
UNSPSC Code:
41116107
MDL number:
MFCD00274576

Key Documents

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InChI

1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3

SMILES string

CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCCC5=N1

InChI key

RAPZEAPATHNIPO-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

risperidone

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... DRD2(1813), HTR2A(3356), HTR2C(3358)

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Related Categories

General description

Risperidone is a new central 5-hydroxytryptamine2 and dopamine D2 antagonist. It is used to treat agitation, aggression,and psychosis caused during demnetia. It is a neuroleptic drug. It is also an atypical antipsychotic drug which is used for treating schizophrenia.

Application

It was used as reference standard during RP-UPLC analysis for determination of risperidone related compounds in Risperdal® Consta (risperidone long-acting injection).

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Legal Information

Risperdal is a registered trademark of Johnson & Johnson

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

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Development and Validation of RP-UPLC Method for Determination of Related Substances in Risperdal? Consta?.
Chen, Cheng-Tung, Cheng-Wei Cheng, and Yu-Fang Hu.
Journal of Chromatography and Separation Techniques, 6.6, 1-1 (2015)
Yvonne Freund-Levi et al.
Dementia and geriatric cognitive disorders, 38(3-4), 234-244 (2014-06-28)
To examine the effects of galantamine and risperidone on agitation in patients with dementia. A total of 100 patients with dementia and neuropsychiatric symptoms (mean age ± SD: 78.6 ± 7.5 years; 67% female) were included in this 12-week, randomized
A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia.
Brodaty H
The Journal of Clinical Psychiatry, 64(2), 134-143 (2003)
Andrea L Cartwright et al.
The Annals of pharmacotherapy, 47(3), 350-360 (2013-03-07)
To summarize and evaluate the pharmacogenetic literature pertaining to the effects of CYP2D6 polymorphism on clinical outcomes of risperidone therapy. A systematic literature search was performed using the search terms risperidone, pharmacogenetics, cytochrome P-450 enzyme system, cytochrome P-450 CYP2D6, and
A comparison of risperidone and haloperidol for the prevention of relapse in patients with schizophrenia.
Csernansky JG
The New England Journal of Medicine, 346(1), 16-22 (2002)
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