03-0145-00
SMC® Amyloid Beta 1-40 High Sensitivity Immunoassay Kit
Used for ultrasensitive quantification of Amyloid Beta 1-40 (Aβ40) in human, rat or mouse plasma or cerebrospinal fluid (CSF)
Synonym(s):
Abeta 1-40 immunoassay kit, Abeta 40 Single Molecule Counting kit, Abeta 40 immunoassay kit, Abeta 40 ultra-sensitive immunoassay
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Usage:
kit sufficient for 96 wells
Compatibility:
for use with FemtoQuest™ and SMCxPRO® instruments
General description
Amyloid Beta 1-40 (Aβ1-40) is a peptide that arises from the proteolytic cleavage of the amyloid precursor protein (APP), a transmembrane protein thought to be involved in neuronal development and function. Aβ1-40 is one of the most common isoforms generated from APP, alongside Aβ1-42, which is more toxic and associated with the formation of amyloid plaques in neurodegenerative diseases.
Aβ1-40 plays a significant role in the pathophysiology of Alzheimer′s disease. Elevated levels of Aβ1-40 in the brain can contribute to neuroinflammation and neuronal damage, disrupting cell signaling and promoting the formation of amyloid plaques. These plaques are characteristic of AD and are believed to trigger a cascade of neurodegenerative processes, leading to cognitive decline and other symptoms associated with the disease. Understanding the function and implications of Aβ1-40 is essential for developing effective diagnostic tools and therapeutic strategies aimed at mitigating its harmful effects in neurodegenerative conditions.
Aβ1-40 plays a significant role in the pathophysiology of Alzheimer′s disease. Elevated levels of Aβ1-40 in the brain can contribute to neuroinflammation and neuronal damage, disrupting cell signaling and promoting the formation of amyloid plaques. These plaques are characteristic of AD and are believed to trigger a cascade of neurodegenerative processes, leading to cognitive decline and other symptoms associated with the disease. Understanding the function and implications of Aβ1-40 is essential for developing effective diagnostic tools and therapeutic strategies aimed at mitigating its harmful effects in neurodegenerative conditions.
Application
Neuroscience/Neurological Disorders/Signaling
Features and Benefits
- Exceptional Sensitivity: Detects Amyloid Beta 1-40 at femtogram levels, significantly outperforming conventional ELISA methods.
- Wider Dynamic Range: Minimizes background interference to deliver clearer signals and improved assay reliability.
- Optimized Workflow Efficiency: Automation-compatible reagents streamline lab processes and reduce manual intervention.
- Experienced Technical Support: Supported by skilled field scientists and technical teams with expertise in SMC® assays.
Packaging
96 well assay
Analysis Note
- Sensitivity: LLOQ 5,860 fg/mL* (SMCxPRO® instrument)
- Standard Curve Range: 340-350,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <10%
- Linearity: Plasma: 104% CSF: 109%
- Recovery: Plasma 110% CSF: 100%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
Other Notes
Although Amyloid Beta 40 was detectable in mouse and rat samples, the assay has not been verified for these species.
Legal Information
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Danger
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Chia-Liang Tsai et al.
Journal of clinical medicine, 8(10) (2019-10-09)
Nondemented people with a family history of Alzheimer's disease (ADFH) and the ApoE-4 allele have been demonstrated to show a trend for a higher probability of cognitive decline and aberrant levels of cognitive-related biomarkers. However, the potential interactive effects on
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 03-0145-00 | 04054839166440 |
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