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Merck

219924

4-Hydroxy-3-nitrophenylacetic acid

99%

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About This Item

Linear Formula:
HOC6H3(NO2)CH2CO2H
CAS Number:
10463-20-4
Molecular Weight:
197.14
NACRES:
NA.22
PubChem Substance ID:
24853155
UNSPSC Code:
12352100
EC Number:
233-948-0
MDL number:
MFCD00007122

Product Name

4-Hydroxy-3-nitrophenylacetic acid, 99%

InChI key

QBHBHOSRLDPIHG-UHFFFAOYSA-N

InChI

1S/C8H7NO5/c10-7-2-1-5(4-8(11)12)3-6(7)9(13)14/h1-3,10H,4H2,(H,11,12)

SMILES string

OC(=O)Cc1ccc(O)c(c1)[N+]([O-])=O

assay

99%

mp

146-148 °C (lit.)

solubility

ethanol: soluble 5%, clear, yellow to orange

functional group

carboxylic acid
nitro

Quality Level

100

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Application

4-Hydroxy-3-nitrophenylacetic acid was used in the synthesis of 4-hydroxy-3-nitrophenylacetyl caproic acid.

General description

4-Hydroxy-3-nitrophenylacetic acid enhances the ice-nucleation activity of Xanthomonas campestris.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ8504
MKCW7630
MKCW3245
MKCR2967
MKCM4740

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P Bergqvist et al.
Mucosal immunology, 6(1), 122-135 (2012-07-13)
Whereas gut IgA responses to the microbiota may be multi-centered and diverse, little is known about IgA responses to T-cell-dependent antigens following oral immunizations. Using a novel approach, gut IgA responses to oral hapten (4-hydroxy-3-nitrophenyl)acetyl-cholera toxin (NP-CT) conjugates were followed
Matthew D Taylor et al.
Frontiers in immunology, 11, 1946-1946 (2020-09-10)
Recent studies have demonstrated that induction of a diverse repertoire of memory T cells ("immune education") affects responses to murine cecal ligation and puncture (CLP), the most widely - used animal model of sepsis. Among the documented effects of immune
Masayuki Oda et al.
Molecular immunology, 47(2-3), 357-364 (2009-10-06)
The effect of antibody affinity on molecular forms of immune complexes was investigated by measuring antigen-antibody interactions using surface plasmon resonance (SPR), electrospray ionization time-of-flight mass spectrometry under non-denaturing conditions (MS), analytical ultracentrifugation (AUC), and transmission electron microscopy (TEM). (4-Hydroxy-3-nitrophenyl)acetic
H Torigoe et al.
The Journal of biological chemistry, 270(38), 22218-22222 (1995-09-22)
To understand the mechanism of affinity maturation, we examined the antigen-antibody interactions between 4-hydroxy-3-nitrophenylacetyl (NP) caproic acid and the Fab fragments of three anti-NP antibodies, N1G9, 3B44, and 3B62, by isothermal titration calorimetry. The analyses have revealed that all of
Ryota Sato et al.
International immunology, 32(8), 499-507 (2020-02-16)
Aluminum precipitates have long been used as adjuvants for human vaccines, but there is a clear need for safer and more effective adjuvants. Here we report in a mouse model that the psoriasis drug Oxarol ointment is a highly effective
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