79380
Phosgene solution
~20% in toluene
Synonym(s):
Carbon oxychloride, Carbonyl chloride, Phosgen
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About This Item
Linear Formula:
COCl2
CAS Number:
Molecular Weight:
98.92
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1098367
Form:
solution
form
solution
Quality Level
reaction suitability
reaction type: Carbonylations
concentration
~20% in toluene
impurities
≤300 mg/kg benzene
functional group
chloro
storage temp.
2-8°C
SMILES string
ClC(Cl)=O
InChI
1S/CCl2O/c2-1(3)4
InChI key
YGYAWVDWMABLBF-UHFFFAOYSA-N
General description
Phosgene is an organic chemical compound widely used as a chlorinating agent, carbonylating agent, and dehydrating agent in organic synthesis for the synthesis of various compounds.
Application
Phosgene solution (~20% in toluene) can be used as a reagent in the synthesis of multiblock copolymers via multiple coupling reactions. It is also used in the activation of the hydroxyl groups in poly(ethylene glycol) diol (PEG diol) to synthesize linear multifunctional poly(ethylene glycol).
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Danger
Hazard Classifications
Acute Tox. 2 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT SE 1 Inhalation - STOT SE 3
target_organs
Central nervous system, Lungs
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
39.2 °F - closed cup
flash_point_c
4 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Wen-Li Li et al.
Inhalation toxicology, 23(13), 842-852 (2011-11-01)
The principal acute mode of action of inhaled phosgene gas is related to an increase alveolar fluid exudation under pathologic conditions. This paper considers some aspects in modeling phosgene-induced acute lung injury (ALI) in an acute rat bioassay and whether
Hong-li Chen et al.
Journal of applied toxicology : JAT, 33(1), 71-77 (2011-08-06)
Phosgene is a poorly water-soluble gas penetrating the lower respiratory tract which can induce acute lung injury characterized by a latent phase of fatal pulmonary edema. Pulmonary edema caused by phosgene is believed to be a consequence of oxidative stress
Pradip Kundu et al.
Analytical chemistry, 84(10), 4594-4597 (2012-04-11)
Phosgene is a very toxic gas, which was used as a chemical weapon in World War I, and is currently widely used in industrial processes. So far, no any phosgene fluorescent sensor has been reported. In this study, we report