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Merck

218772

Caspase Inhibitor Set II - Calbiochem

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UNSPSC Code:
12352200

Key Documents

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form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-1, caspase-2, caspase-4, caspase-5, caspase-6, caspase-7, caspase-8, caspase-9
Reversible: no
Secondary Target
granzyme B

Disclaimer

Toxicity: Standard Handling (A)

General description

This product has been discontinued.



A set of eight cell-permeable, irreversible inhibitors of various caspase-family proteases. Contains 250 µg each of Caspase-1 Inhibitor VI, Z-YVAD-FMK (Cat. No. 218746); Caspase-2 Inhibitor I, Z-VDVAD-FMK (Cat. No. 218744); Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264155); Caspase-5 Inhibitor I, Z-WEHD-FMK (Cat. No. 218753); Caspase-6 Inhibitor I, Z-VEID-FMK (Cat. No. 218757); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 218759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No. 218761); and Caspase Inhibitor III, Boc-D-FMK (Cat. No. 218745). Supplied with a data sheet.

Apoptosis is a normal process in development and morphogenesis. Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. Receptor-mediated apoptosis involves the activation of caspases (cysteine-containing aspartate-specific proteases). A distinctive feature of caspases is the requirement of an aspartic acid residue in the substrate P1 position.



Caspase inhibitors act by binding to the active site of caspases and form either a reversible or an irreversible linkage. Caspase inhibitor design includes a peptide recognition sequence attached to a functional group such as an aldehyde (CHO), chloromethylketone (CMK), fluoromethylketone (FMK), or fluoroacyloxymethylketone (FAOM). Caspase inhibitors with a CHO group are reversible and those with a CMK, FMK, or FAOM group are irreversible. FMK exhibits slightly less reactivity than CMK and therefore is more specific for the enzyme being inhibited.

Other Notes

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Humke, E.W., et al. 1998. J. Biol. Chem.273, 15702.
Takahashi, A., et al. 1997. Exp. Cell Res.231, 123.
Thornberry, N.A., et al. 1997. J. Biol. Chem.272, 17907.
Nicholson, D.W., et al. 1995. Nature376, 37.
Thornberry, N.A., et al. 1992. Nature356, 768.

Preparation Note

From Catalog:

Desc. Field- added "A set of eight cell-permeable, irreversible inhibitors of various caspase-family proteases"

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

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