PMB3004
L-Leucine
98.5-101%, ISOM8™, suitable for cell culture, from non-animal source
Synonym(s):
L-Leucine, (S)-2-Amino-4-methylpentanoic acid, (S)-Leucine, (S)-2-Amino-4-methylpentanoic acid
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About This Item
Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
131.17
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
1721722
MDL number:
biological source
non-animal source
Quality Segment
agency
meets EP, meets JP, meets USP, meets requirements for USP (testing)
product line
ISOM8™
assay
98.5-101%
form
crystalline powder
optical activity
[α]/D 14.9-16°, c = 6 M in HCl (4 in 6M HCl)
technique(s)
cell culture | mammalian: suitable
color
white
mp
>300 °C
solubility
HCl: 50 mg/mL (1M)
functional group
amine, carboxylic acid
storage temp.
room temp
SMILES string
CC(C)C[C@H](N)C(O)=O
InChI
1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChI key
ROHFNLRQFUQHCH-YFKPBYRVSA-N
General description
L-Leucine is a branched-chain essential amino acid (BCAA). It is one of the nine essential amino acids that must be supplemented in culture systems, as it cannot be synthesized de novo by animal cells. L-Leucine plays a critical role in protein biosynthesis, metabolic regulation, and cellular signaling pathways. In biological systems, L-Leucine is primarily involved in initiating the translation process and promoting ribosomal protein synthesis, particularly through activation of the mTOR (mechanistic target of rapamycin) pathway—a key regulator of cell growth, proliferation, and metabolism. It also serves as a substrate for energy production under nutrient-limiting conditions and contributes to the synthesis of other important biomolecules, such as sterols and fatty acids.
Features and Benefits
Features:
1. Qualified Raw Materials: Products that meet the stringent requirements of the Elevated Assurance Program, ensuring compliance with regulatory standards.
2. Comprehensive Documentation: Includes essential documents such as certificates, impurity profiles, and declarations to support audits and risk assessments.
3. M-Clarity™ Quality Attributes: Products are classified within the MQ300 quality segment or higher, demonstrating superior quality assurance. https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/m-clarity-program
4. Confirmed Process Controls: Established processes that ensure consistency and reliability in manufacturing.
5. Enhanced Change Notification: Timely updates on any changes to product specifications or processes, ensuring transparency and compliance.
6. Freely Available Dossiers: Access to robust, ready-to-present product dossiers that include:
Benefits:
1. Regulatory Compliance: Helps you meet compliance standards effectively, reducing the risk of regulatory issues.
2. Audit Readiness: Instills confidence during audits with comprehensive documentation and confirmed process controls, demonstrating your commitment to high-quality products.
3. Operational Transparency: Supports supply chain transparency, allowing you to track and verify the quality of raw materials.
4. Enhanced Support: Provides exceptional quality-related information and tailored assistance to meet your specific needs.
5. Risk Mitigation: Facilitates thorough risk assessments with detailed documentation, helping you manage potential compliance challenges.
6. Informed Decision-Making: Access to clear and comprehensive product information enables better decision-making and enhances operational efficiency.
1. Qualified Raw Materials: Products that meet the stringent requirements of the Elevated Assurance Program, ensuring compliance with regulatory standards.
2. Comprehensive Documentation: Includes essential documents such as certificates, impurity profiles, and declarations to support audits and risk assessments.
3. M-Clarity™ Quality Attributes: Products are classified within the MQ300 quality segment or higher, demonstrating superior quality assurance. https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/m-clarity-program
4. Confirmed Process Controls: Established processes that ensure consistency and reliability in manufacturing.
5. Enhanced Change Notification: Timely updates on any changes to product specifications or processes, ensuring transparency and compliance.
6. Freely Available Dossiers: Access to robust, ready-to-present product dossiers that include:
- Site quality assessment
- ISO 9001 certificate
- Detailed product specifications
- Relevant declarations/statements (e.g., animal origin content, BSE/TSE, nitrosamine)
Benefits:
1. Regulatory Compliance: Helps you meet compliance standards effectively, reducing the risk of regulatory issues.
2. Audit Readiness: Instills confidence during audits with comprehensive documentation and confirmed process controls, demonstrating your commitment to high-quality products.
3. Operational Transparency: Supports supply chain transparency, allowing you to track and verify the quality of raw materials.
4. Enhanced Support: Provides exceptional quality-related information and tailored assistance to meet your specific needs.
5. Risk Mitigation: Facilitates thorough risk assessments with detailed documentation, helping you manage potential compliance challenges.
6. Informed Decision-Making: Access to clear and comprehensive product information enables better decision-making and enhances operational efficiency.
Legal Information
ISOM8 is a trademark of Sigma-Aldrich Co. LLC
M-CLARITY is a trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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