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Merck

Y0001404

Vigabatrin impurity D

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

γ-Aminobutyric acid, 3-Carboxypropylamine, 4-Aminobutanoic acid, GABA, Piperidic acid, Piperidinic acid

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About This Item

Linear Formula:
NH2(CH2)3COOH
CAS Number:
Molecular Weight:
103.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
906818

Product Name

Vigabatrin impurity D, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

SMILES string

NCCCC(O)=O

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

vigabatrin

manufacturer/tradename

EDQM

mp

195 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Application

Vigabatrin impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Major inhibitory neurotransmitter in brain; GABAA and GABAB receptor agonist; increases Cl conductance.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Melissa A Farmer et al.
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A D Stan et al.
Molecular psychiatry, 20(4), 433-439 (2014-06-11)
Hippocampal dysfunction in schizophrenia is widely acknowledged, yet the mechanism of such dysfunction remains debated. In this study we investigate the excitatory and inhibitory hippocampal neurotransmission using two complementary methodologies, proton magnetic resonance spectroscopy (MRS) and tissue biochemistry, sampling individuals
Jesse Jackson et al.
Nature neuroscience, 17(10), 1362-1370 (2014-09-01)
Activity flow through the hippocampus is thought to arise exclusively from unidirectional excitatory synaptic signaling from CA3 to CA1 to the subiculum. Theta rhythms are important for hippocampal synchronization during episodic memory processing; thus, it is assumed that theta rhythms
Hussein A N Al-Wadei et al.
Molecular nutrition & food research, 55(12), 1745-1758 (2011-08-02)
GABA is a bioactive constituent of fruits, vegetables, cereals and is believed to play a role in defense against stress in plants. In animals, it acts as an inhibitory neurotransmitter in brain while also expressed in non-neuronal cells. Studies have

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