A9920
β-Alanine
BioReagent, suitable for cell culture, suitable for insect cell culture
Synonym(s):
β-Ala, 3-Aminopropionic acid
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About This Item
Linear Formula:
NH2CH2CH2COOH
CAS Number:
Molecular Weight:
89.09
NACRES:
NA.75
PubChem Substance ID:
eCl@ss:
39030936
UNSPSC Code:
12352209
EC Number:
203-536-5
MDL number:
Beilstein/REAXYS Number:
906793
product line
BioReagent
Quality Level
assay
≥98% (TLC)
form
powder or crystals
technique(s)
cell culture | insect: suitable, cell culture | mammalian: suitable
color
white
mp
202 °C (dec.) (lit.)
InChI
1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)
InChI key
UCMIRNVEIXFBKS-UHFFFAOYSA-N
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General description
An N-blocked form of alanine.
Biochem/physiol Actions
Endogenous β-amino acid that is a nonselective agonist at glycine receptors and a ligand for the G protein-coupled orphan receptor, TGR7 (MrgD). β-Alanine is a component of pantothenic acid.
β-Alanine, a β−amino acid, is a component of pantothenic acid and the rate-limiting amino acid in the biosynthesis of the histidinyl antioxidant dipeptides carnosine and anserine. Endogenous β-amino acid that is a nonselective agonist at glycine receptors and a ligand for the G protein-coupled orphan receptor, TGR7 (MrgD). β-Alanine flux plays a cytoprotective role by supporting the osmotic stability of marine organisms, preimplantation mouse embryos and mammalian cells exposed to hypoxic stress.
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Robert G Hart et al.
The Canadian journal of cardiology, 29(7 Suppl), S71-S78 (2013-06-29)
Chronic kidney disease (CKD) is prevalent in elderly patients with atrial fibrillation and is an independent risk factor for stroke. Warfarin anticoagulation is efficacious for stroke prevention in atrial fibrillation patients with moderate CKD (stage III, estimated glomerular filtration rate
Ammar Majeed et al.
Circulation, 128(21), 2325-2332 (2013-10-02)
The aim of this study was to compare the management and prognosis of major bleeding in patients treated with dabigatran or warfarin. Two independent investigators reviewed bleeding reports from 1034 individuals with 1121 major bleeds enrolled in 5 phase III
Wim Derave et al.
Sports medicine (Auckland, N.Z.), 40(3), 247-263 (2010-03-05)
Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is synthesized by carnosine synthase from the amino acids L-histidine and beta-alanine, of which the latter is the rate-limiting precursor, and degraded by carnosinase. Recent studies have
Trent Stellingwerff et al.
Amino acids, 43(1), 57-65 (2012-02-24)
Interest into the effects of carnosine on cellular metabolism is rapidly expanding. The first study to demonstrate in humans that chronic β-alanine (BA) supplementation (~3-6 g BA/day for ~4 weeks) can result in significantly augmented muscle carnosine concentrations (>50%) was
Torben Bjerregaard Larsen et al.
The American journal of medicine, 127(4), 329-336 (2013-12-24)
Dabigatran may provide less protection against myocardial infarction than vitamin K antagonists (VKAs) in patients with atrial fibrillation. This may be particularly evident among "switchers" to dabigatran from VKA, as a result of discontinuation effects. We identified in nationwide Danish
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