G2879

Glycine hydrochloride

Name: Glycine hydrochloride
Brand: SIGMA

≥99% (HPLC), NMDA receptors regulator, powder

Synonym(s):

Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:

H₂NCH₂CO₂H · HCl

CAS Number:

6000-43-7

Molecular Weight:

111.53

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24895108

NACRES:

NA.32

EC Number:

227-841-8

MDL number:

MFCD00012872

Product Name

Glycine hydrochloride, ≥99% (HPLC)

SMILES string

Cl.NCC(O)=O

InChI

1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H

InChI key

IVLXQGJVBGMLRR-UHFFFAOYSA-N

assay

≥99% (HPLC)

form

powder

mol wt

111.53

storage condition

(Tightly closed Dry)

concentration

≤100%

technique(s)

immunohistochemistry: suitable

mp

176-180 °C (lit.)

solubility

water: 0.5 g/mL, clear, colorless

storage temp.

room temp

Quality Level

300

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Bioactive Small Molecules

Application

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.

Glycine hydrochloride has been used:

in the preparation of glycine-HCl buffer
to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
to regenerate the sensor to elute the bound C-reactive protein (CRP)

Biochem/physiol Actions

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.

Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

General description

Research area: Neuroscience

pictograms

GHS05

signalword

Danger

hcodes

H314

pcodes

P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Glycine: a new anti-inflammatory immunonutrient.

M D Wheeler et al.

Cellular and molecular life sciences : CMLS, 56(9-10), 843-856 (2001-02-24)

The mechanism of the immunosuppressive effects of glycine and its pathophysiological applications are discussed in this review. Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes.

Multispectral Imaging of T and B Cells in Murine Spleen and Tumor.

Zipei Feng et al.

Journal of immunology (Baltimore, Md. : 1950), 196(9), 3943-3950 (2016-03-20)

Recent advances in multiplex immunohistochemistry techniques allow for quantitative, spatial identification of multiple immune parameters for enhanced diagnostic and prognostic insight. However, applying such techniques to murine fixed tissues, particularly sensitive epitopes, such as CD4, CD8α, and CD19, has been

Glycine

Hall JC

JPEN. Journal of parenteral and enteral nutrition, 22(6), 393-398 (2019)

Coupling of HIV-1 gp120-derived Core Protein to Paramagnetic Beads and Adsorption Assays

Ingale J and Wyatt RT

Bio-protocol, 5(20) (2015)

Hydrolysis of organic phosphates by commercially available phytases: Biocatalytic potentials and effects of ions on their enzymatic activities

Tazisong IA, et al.

Journal of food, agriculture & environment, 6(3&4), 500-505 (2008)

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