G8790

Glycine

Name: Glycine
Brand: SIGMA

≥98.5%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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All Photos(3)

About This Item

Linear Formula:

NH₂CH₂COOH

CAS Number:

56-40-6

Molecular Weight:

75.07

NACRES:

NA.26

PubChem Substance ID:

24895353

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-272-2

MDL number:

MFCD00008131

Beilstein/REAXYS Number:

635782

Product Name

Glycine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, ≥98.5%

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

SMILES string

NCC(O)=O

biological source

non-animal source

agency

meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

assay

≥98.5%

form

powder

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

pH

5.9-6.4

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

solubility

H₂O: 100 mg/mL

Quality Level

300

Gene Information

rat ... Grin2a(24409)

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Related Categories

Amino Acids

Biochemicals

Cell Culture Supplements & Reagents

Chemistry & Biochemicals

Application

Amino acid for use in cell culture media development applications and existing media formulations.

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000501164

0000506695

0000506554

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Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes.

Alexander Carvajal-González et al.

Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)

The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.

The superior paraolivary nucleus shapes temporal response properties of neurons in the inferior colliculus.

Richard A Felix et al.

Brain structure & function, 220(5), 2639-2652 (2014-06-30)

The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route

Differential GABAergic and glycinergic inputs of inhibitory interneurons and Purkinje cells to principal cells of the cerebellar nuclei.

Zoé Husson et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9418-9431 (2014-07-11)

The principal neurons of the cerebellar nuclei (CN), the sole output of the olivo-cerebellar system, receive a massive inhibitory input from Purkinje cells (PCs) of the cerebellar cortex. Morphological evidence suggests that CN principal cells are also contacted by inhibitory

Intermediate filament protein accumulation in motor neurons derived from giant axonal neuropathy iPSCs rescued by restoration of gigaxonin.

Bethany L Johnson-Kerner et al.

Human molecular genetics, 24(5), 1420-1431 (2014-11-16)

Giant axonal neuropathy (GAN) is a progressive neurodegenerative disease caused by autosomal recessive mutations in the GAN gene resulting in a loss of a ubiquitously expressed protein, gigaxonin. Gene replacement therapy is a promising strategy for treatment of the disease;

The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.

Dmitrij A Lisak et al.

Biochimica et biophysica acta, 1853(9), 2104-2114 (2015-03-15)

Bax inhibitor-1 (BI-1) is an evolutionarily conserved pH-dependent Ca²⁺ leak channel in the endoplasmic reticulum and the founding member of a family of six highly hydrophobic mammalian proteins named transmembrane BAX inhibitor motif containing (TMBIM) 1-6 with BI-1 being TMBIM6.

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