M1777
N-Methyl-1-deoxynojirimycin
≥98%
Synonym(s):
1,5-Dideoxy-1,5-imino-1-methyl-D-sorbitol
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About This Item
Empirical Formula (Hill Notation):
C7H15NO4
CAS Number:
Molecular Weight:
177.20
UNSPSC Code:
51102829
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1524564
biological source
synthetic (organic)
Quality Level
assay
≥98%
form
powder
solubility
methanol: 10 mg/mL, clear, colorless
antibiotic activity spectrum
viruses
mode of action
enzyme | inhibits
storage temp.
−20°C
SMILES string
CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChI
1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
InChI key
AAKDPDFZMNYDLR-XZBKPIIZSA-N
Gene Information
mouse ... Gaa(14387), Glb1(12091), Treh(58866)
rat ... Man2a1(25478), Si(497756)
General description
Chemical structure: glucosamine
Biochem/physiol Actions
Interferes with metabolism of N-linked glycoproteins by inhibition of glucosidase.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Diego A Caraballo et al.
G3 (Bethesda, Md.), 10(2), 755-768 (2019-12-05)
UDP- glucose: glycoprotein glucosyltransferase (UGGT) is a protein that operates as the gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein folding. It is known that vertebrates and Caenorhabditis genomes harbor two uggt gene copies that exhibit differences
J C Ridruejo et al.
Biochimica et biophysica acta, 993(2-3), 179-185 (1989-12-08)
Castanospermine, 1-deoxynojirimycin, and N-methyl-1-deoxynojirimycin, three well-characterized inhibitors of the glucosidases involved in the processing of N-linked oligosaccharides, did not affect the biosynthesis or the secretion of exoglucanases (EC 3.2.1.58) from Saccharomyces cerevisiae and Candida albicans but inhibited the activity itself.
P F Daniel et al.
American journal of medical genetics, 42(4), 586-592 (1992-02-15)
In agreement with reports from other laboratories, we have shown that patients with the juvenile or late infantile forms of neuronal ceroid-lipofuscinosis (NCL) have greatly increased levels (5-fold to 20-fold) of dolichyl pyrophosphoryl oligosaccharides in their cerebral gray matter. Oligosaccharides