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Merck

P8477

Picotamide

Synonym(s):

4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide

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About This Item

Empirical Formula (Hill Notation):
C21H20N4O3
CAS Number:
32828-81-2
Molecular Weight:
376.41
NACRES:
NA.83
PubChem Substance ID:
24278656
UNSPSC Code:
12352204
EC Number:
251-245-7
MDL number:
MFCD00866792

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InChI

1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)

InChI key

KYWCWBXGRWWINE-UHFFFAOYSA-N

SMILES string

COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3

assay

≥98%

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless to light yellow

Quality Level

100

Gene Information

human ... TBXA2R(6915)

Biochem/physiol Actions

Eicosenoid receptor antagonist; a thromboxane A2 antagonist; antiplatelet agent.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV7226
MKCT3927
MKCS6640
MKCF5004
MKBW5293V

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P A Modesti et al.
European journal of pharmacology, 169(1), 85-93 (1989-10-04)
On the basis of indirect pharmacological evidence, picotamide, a methoxy derivative of 4-hydroxy-isophthalic acid (N,N'bis(3-picolyl)-4-methoxy-isophthalamide) has been postulated to inhibit platelet aggregation by competitively interfering with the thromboxane A2 (TxA2) platelet receptor. In the present study the interaction between picotamide
A Giustina et al.
Diabetes, 47(3), 423-430 (1998-03-31)
Picotamide both inhibits thromboxane synthetase and acts as a thromboxane antagonist at the receptor level. We investigated the long-term effect of picotamide on urinary albumin excretion (UAE) at rest and induced by exercise in 30 type 2 diabetic patients who
M Y Abeywardena et al.
Prostaglandins, leukotrienes, and essential fatty acids, 65(2), 91-97 (2001-09-08)
Two currently available edible oils-olive and canola-and two oil blends of plant origin having different n-3/n-6 polyunsaturated fatty acid (PUFA) ratios were evaluated for their ability to modify vascular dysfunction in the spontaneously hypertensive rat (SHR). Synthetic diets supplemented with
G Bettinetti et al.
Journal of pharmaceutical sciences, 88(11), 1133-1139 (1999-11-17)
Picotamide is an antiplatelet agent given by mouth as monohydrate (PICOW) (Plactidil) in thrombo-embolic disorders. This study deals with physical characterization of PICOW recrystallized from various solvents and the respective dehydration products using X-ray powder diffractometry (XRD), infrared spectroscopy (IR)
Matthew Hotston et al.
BJU international, 106(11), 1794-1798 (2010-05-27)
To explore the possible role of of 8-isoprostane F(2α) (8-IPF(2α) ) in the aetiology of erectile dysfunction (ED), as the over-production of superoxide (O(2)(-)) derived from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase results in the formation of 8-IPF(2α) in vascular
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