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Merck

T0307

Tyloxapol

BioXtra

Synonym(s):

4-(1,1,3,3-Tetramethylbutyl)phenol polymer with formaldehyde and oxirane

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About This Item

CAS Number:
25301-02-4
NACRES:
NA.25
PubChem Substance ID:
24899881
UNSPSC Code:
12161900
MDL number:
MFCD00149002

Key Documents

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InChI

1S/C14H22O.C2H6O2.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;3-1-2-4;1-2/h6-9,15H,10H2,1-5H3;3-4H,1-2H2;1H2

SMILES string

[H]C([H])=O.OCCO.CC(C)(C)CC(C)(C)c1ccc(O)cc1

InChI key

GWJOFBXSBDVUMH-UHFFFAOYSA-N

description

non-ionic

product line

BioXtra

impurities

<0.0005% Phosphorus (P)

ign. residue

<1.0%

CMC

0.018 mM

transition temp

cloud point 94.3 °C

anion traces

chloride (Cl-): <0.05%, sulfate (SO42-): <0.6%

cation traces

Al: <0.0005%, Ca: <0.0005%, Cu: <0.0005%, Fe: <0.001%, K: <0.005%, Mg: <0.0005%, NH4+: <0.05%, Na: <0.5%, Pb: <0.001%, Zn: <0.0005%

Quality Level

100

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Related Categories

General description

A nonionic liquid polymer of the alkyl aryl polyether alcohol type. Used as a surfactant.
Tyloxapol is a biocompatible surfactant

Application

Tyloxapol has been used in a study to assess the enhanced pulmonary absorption of recombinant human insulin. It has also been used in a study to investigate the metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCR4287
MKCQ1034
MKCK7328
MKCH6508
MKCF6494

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Martina Theresa Hackl et al.
Nature communications, 10(1), 2717-2717 (2019-06-22)
Hepatic steatosis develops when lipid influx and production exceed the liver's ability to utilize/export triglycerides. Obesity promotes steatosis and is characterized by leptin resistance. A role of leptin in hepatic lipid handling is highlighted by the observation that recombinant leptin
Jianheng Zheng et al.
Die Pharmazie, 67(5), 448-451 (2012-07-07)
Natural pulmonary surfactant (PS) and its artificial substitute phospholipid hexadecanol tyloxapol (PHT) are effective absorption enhancers on promoting recombinant human insulin (Rh-ins) absorption in vivo, but the in vitro efficacy and underlying mechanism remains unclear. In the current study, the
Adejuwon Adewale Adeneye et al.
Journal of ethnopharmacology, 130(2), 307-314 (2010-05-18)
In Nigerian folk medicine, water infusion of the dried seeds of Hunteria umbellata (K. Schum.) Hallier f. has a reputation for the local management of obesity and hyperlipidaemia. The present study is aimed at evaluating the anti-obesity and antihyperlipidaemic activities
Panneerselvam Vijayaraj et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 65(1-2), 135-141 (2011-08-20)
The flower extract of Cassia auriculata, herb has been used traditionally in India for medicinal purposes. The plant has been reported to treat hyperglycemia and associated hyperlipidemia. Hyperlipidemia and oxidative stress are known to accelerate coronary artery disease and progression
Juliana Trevisan da Rocha et al.
The Journal of pharmacy and pharmacology, 61(12), 1673-1679 (2009-12-05)
A significant association between the trace element selenium and hypercholesterolaemia has been reported. This study was designed to investigate a potential hypolipidaemic effect of diphenyl diselenide ((PhSe)(2)) in Triton WR-1339-induced hyperlipidaemia in mice. Triton was administered intraperitoneally (400 mg/kg) to
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