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Merck

1316004

USP

Hydrocortisone

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M

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About This Item

Empirical Formula (Hill Notation):
C21H30O5
CAS Number:
50-23-7
Molecular Weight:
362.46
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329750063
MDL number:
MFCD00011654
Beilstein/REAXYS Number:
1354819

Product Name

Hydrocortisone, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

grade

pharmaceutical primary standard

API family

hydrocortisone

manufacturer/tradename

USP

mp

211-214 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... NR3C1(2908)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Hydrocortisone USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard stock, standard, and system suitability solution for assay, identification, and performance test by liquid chromatography in accordance with the given below monographs of United States Pharmacopeia (USP) :
  • Hydrocortisone Sodium Succinate for Injection
  • Hydrocortisone Tablets
  • Hydrocortisone Gel
  • Hydrocortisone Lotion

Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex.
Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Repr. 1A - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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Hydrocortisone Gel
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(6), 2230-2230 (2020)
Hydrocortisone Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(6), 2234-2234 (2023)
Hydrocortisone Lotion
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 45(3), 2232-2232 (2013)
Hydrocortisone Sodium Succinate for Injection
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 2243- 2243 (2018)
Florian Hardeveld et al.
Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
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