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Merck

435449

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

average Mn ~2,900

Synonym(s):

Nanopatterning, Pluronic® L-64, block-copolymers, PEG-PPG-PEG

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About This Item

CAS Number:
9003-11-6
UNSPSC Code:
12352104
PubChem Substance ID:
24867234
NACRES:
NA.23
MDL number:
MFCD00082049

Key Documents

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vapor density

>1 (vs air)

Quality Level

200

vapor pressure

<0.3 mmHg ( 20 °C)

form

viscous liquid

mol wt

average Mn ~2,900

composition

PEG, 40 wt. %

refractive index

n20/D 1.46

surface tension

43 dyn/cm, 25 °C, 0.1 wt. % in H2O

viscosity

850 cP(25 °C, Brookfield)(lit.)

transition temp

cloud point 58 °C (1 wt. % aqueous solution)

density

1.05 g/mL at 25 °C

HLB

12.0 - 18.0

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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Application

Hard and soft surface cleaners, defoamers in coatings and water treatment. Lubricant in metal working, anti-foaming aid and extender for linear and cross-linked polyesters and polyurethanes.

Features and Benefits

Surface active material whose properties are dependent on the hydrophilic (EO)/hydrophobic (PO) ratio. High EO content gives better o/w stabilizers.

Physical form

Terminal primary dihydroxy-functional oligomer.

Legal Information

Pluronic is a registered trademark of BASF

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Storage Class

11 - Combustible Solids

wgk

WGK 1

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ9725
MKCZ4149
MKCX5922
MKCW3532
MKCT8242

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Wei Xu et al.
Drug delivery, 19(4), 208-219 (2012-05-31)
The aim of this study was to construct novel targeting polymeric micelles. Folate-Poly (ethylenimine)-Pluronic copolymers were synthesized. A paclitaxel (PTX)-loaded mixed micelles consisting of Folate-Poly (ethylenimine)-Pluronic and Pluronic L121 copolymers have been developed. The mixed micelles showed nano-sized spherical morphology.
Liyan Zhao et al.
Colloids and surfaces. B, Biointerfaces, 97, 101-108 (2012-05-23)
In this study, curcumin (Cur) loaded mixed micelles (Cur-PF), composed of Pluronic P123 (P123) and Pluronic F68 (F68), was prepared using the thin-film hydration method and evaluated in vitro. The preparation process was optimized with a central composite design (CCD).
Jianan Shen et al.
Biomaterials, 34(5), 1581-1590 (2012-11-14)
The metastasis of breast cancer is the leading cause of cancer death in women, and the lung is a common location of a secondary tumor that has metastasized from the primary source tumor. In this work, an attempt to simultaneously
Laurien Buitinga et al.
Clinical and experimental rheumatology, 29(5), 783-789 (2011-10-04)
The Time Trade-Off (TTO) is an instrument used for valuing health-related quality of life. This study evaluated the test-retest reliability of a computer TTO in rheumatoid arthritis (RA), and compared the computer with the interview TTO regarding feasibility and agreement.
Tsz Chung Lai et al.
Colloids and surfaces. B, Biointerfaces, 99, 27-37 (2011-10-18)
Polyplex particles formed with plasmid DNA (pDNA) and Pluronic P85-block-poly{N-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} (P85-b-P[Asp(DET)]) demonstrated highly effective transfection ability compared to PEG-based block cationomer, PEG-b-P[Asp(DET)]. Ternary polyplexes comprising PEG-b-P[Asp(DET)], poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-P[Asp(DET)] (P(EPE)-b-P[Asp(DET)]) used as an analog of P85-b-P[Asp(DET)], and pDNA were
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