86734
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
≥97.0% (CHN)
Synonym(s):
DOTA
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About This Item
Empirical Formula (Hill Notation):
C16H28N4O8 · xH2O
CAS Number:
Molecular Weight:
404.42 (anhydrous basis)
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1186987
Assay:
≥97.0% (CHN)
Form:
powder
InChI
1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)
SMILES string
OC(=O)CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O
InChI key
WDLRUFUQRNWCPK-UHFFFAOYSA-N
assay
≥97.0% (CHN)
form
powder
functional group
carboxylic acid
Quality Level
Application
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.
- It has been used for radiolabeling of carbon nanotube bioconjugates by chelating 64Cu radioisotope.
- DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
- It can form complexes with gadolinium for application as MRI contrast agents.
- Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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The synthesis and chelation chemistry of DOTA- peptide conjugates.
De Leon-Rodriguez LM and Kovacs Z
Bioconjugate Chemistry, 19(2), 391-402 (2007)
An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA.
Lewis MR, et al.
Bioconjugate Chemistry, 12(2), 320-324 (2001)
Javad Garousi et al.
Scientific reports, 7(1), 5961-5961 (2017-07-22)
Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imaging of EGFR expression in tumours may aid in selection of optimal cancer therapy. The
Luca Garbuio et al.
The journal of physical chemistry. B, 117(11), 3145-3153 (2013-02-28)
We present the first example of chemoselective site-specific spin labeling of a monomeric protein with two spectroscopically orthogonal spin labels: a gadolinium(III) chelate complex and a nitroxide radical. A detailed analysis of the performance of two commercially available Gd(III) ligands
Sara S Rinne et al.
International journal of molecular sciences, 21(6) (2020-03-19)
HER3-binding affibody molecules are a promising format for visualization of HER3 expression. Cobalt-55, a positron-emitting isotope, with a half-life of 17.5 h, allows for next-day imaging. We investigated the influence of the charge of the radiocobalt-chelator complex on the biodistribution
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