K1757

Keratinocyte Growth Factor human

Name: Keratinocyte Growth Factor human
Brand: SIGMA

≥95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, powder, suitable for cell culture

Synonym(s):

hFGF-7, hKGF, FGF-7, KGF

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About This Item

CAS Number:

148348-15-6

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00212245

Product Name

Keratinocyte Growth Factor human, KGF, recombinant, expressed in E. coli, powder, suitable for cell culture

biological source

human

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE and HPLC)

form

powder

potency

0.1-15 ng/mL ED₅₀/EC₅₀

quality

endotoxin tested

mol wt

18.9 kDa

packaging

pkg of 10 and 50 μg

technique(s)

cell culture | mammalian: suitable

impurities

1 EU/μg

UniProt accession no.

P21781

storage temp.

−20°C

Quality Level

200

Gene Information

human ... FGF7(2252)

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Analysis Note

Determined by a cell proliferation assay using 4MBr-5 cells.

Application

Keratinocyte Growth Factor human has been used:

as a component of epithelial growth medium
as a positive control for antigen to determine the activity of the antibody
to analyze the influence of KGF associated with thermo-sterilized carboxymethyl chitosan (NOCCts) in the reduction of pericardial adhesions

Biochem/physiol Actions

Keratinocyte Growth Factor(KGF) stimulates proliferation and differentiation of keratinocytes and other cells in the epithelium. It induces chemotaxis of microvascular endothelial cells and neovascularization of rat cornea. It stimulates the hyaluronic acid synthesis in proliferating and migrating basal cells. KGF contributes to the survival of cells under stress conditions. KGF is highly expressed in injured and inflamed epithelial cells, thereby, promotes wound healing.

General description

Keratinocyte Growth Factor(KGF) is a 18.9 kDa growth factor, spanning 163 amino acids, belongs to the fibroblast growth factor family. It includes a secretory signal sequence and shares 39% identity with FGF-Basic. It is expressed in a number of stromal fibroblast cell lines, mesenchymal cells but absent from normal glial cells and epithelial cell lines.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound

Braun S, et al.

Molecular and Cellular Biology, 22(15), 5492-5505 (2002)

Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3

Karvinen S, et al.

The Journal of biological chemistry, 278(49), 49495-49504 (2003)

Stimulation of in vivo angiogenesis by in situ crosslinked, dual growth factor-loaded, glycosaminoglycan hydrogels

Elia R, et al.

Biomaterials, 31(17), 4630-4638 (2010)

Characteristics of MIC-1 antlerogenic stem cells and their effect on hair growth in rabbits.

Cegielski M, et al.

In Vivo, 27(1), 97-106 (2013)

Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration

Alpdogan O, et al.

Blood, 107(6), 2453-2460 (2006)

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