T8200
Tofisopam
≥98% (HPLC), solid
Synonym(s):
7,8-Dimethoxy-1-(3,4-dimethoxyphenyl)-5-ethyl-4-methyl-5H-2,3-benzodiazepine, EGYT 341, Seriel
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About This Item
Empirical Formula (Hill Notation):
C22H26N2O4
CAS Number:
Molecular Weight:
382.45
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
244-922-3
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
color
white
solubility
DMSO: ~14 mg/mL, H2O: insoluble
SMILES string
CCC1C(C)=NN=C(c2ccc(OC)c(OC)c2)c3cc(OC)c(OC)cc13
InChI
1S/C22H26N2O4/c1-7-15-13(2)23-24-22(14-8-9-18(25-3)19(10-14)26-4)17-12-21(28-6)20(27-5)11-16(15)17/h8-12,15H,7H2,1-6H3
InChI key
RUJBDQSFYCKFAA-UHFFFAOYSA-N
Application
Tofisopam has been used for studying its biochemical mechanisms of actions using drug repositioning strategies.
Biochem/physiol Actions
Ligand for the GABAA receptor benzodiazepine modulatory site.
Studies have reported that tofisopam functions by blocking PDE4 (phosphodiesterase 4). Furthermore, the S-enantiomer of tofisopam is considered ten times more active than R-enantiomer.
Preparation Note
Tofisopam is soluble in DMSO at approximately 14 mg/ml. However, it is insoluble in water.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Tofisopam inhibits the pharmacokinetics of CYP3A4 substrate midazolam.
Mária Tóth et al.
European journal of clinical pharmacology, 64(1), 93-94 (2007-11-09)
Yue Fan et al.
Neuroscience letters, 736, 135262-135262 (2020-07-20)
Spinal cord injury (SCI) is a traumatic condition of the central nervous system (CNS) that can cause paralysis of the limbs. The molecular mechanisms of neural repair following SCI remain unclear and no effective treatment for SCI currently exists, since
N P Vanchakova et al.
Bulletin of experimental biology and medicine, 148(2), 343-345 (2009-12-23)
The study demonstrated high anxiolytic activity of tenoten, which was not inferior to the anxiolytic effect of grandaxin. The positive changes persisted after termination of treatment in the tenoten group (but not in grandaxin group). Tenoten can be recommended for