764752
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)
PEG average Mn 5,000, PLGA Mn 55,000
Synonym(s):
PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA, mPEG-b-PLGA
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
NACRES:
NA.23
UNSPSC Code:
12162002
description
typical PEG PDI < 1.1; overall PDI < 2.5
Quality Level
form
pellets
feed ratio
lactide:glycolide 50:50
mol wt
PEG average Mn 5,000, PLGA Mn 55,000, average Mn 60,000 (total)
degradation timeframe
1-4 weeks
transition temp
Tg 10 °C(lit.), Tm 254-259 °C
PDI
<1.2
storage temp.
2-8°C
General description
Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.
Application
Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
Features and Benefits
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
Still not finding the right product?
Explore all of our products under Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Hunter Bachman et al.
Lab on a chip, 20(7), 1238-1248 (2020-02-28)
Whether reagents and samples need to be combined to achieve a desired reaction, or precise concentrations of solutions need to be mixed and delivered downstream, thorough mixing remains a critical step in many microfluidics-based biological and chemical assays and analyses.
Thermosensitive self-assembling block copolymers as drug delivery systems
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., & Palmieri, G. F.
Polymers (Basel, Switzerland), 3(2), 779-811 (2011)
Sara Moufarrij et al.
Scientific reports, 10(1), 3470-3470 (2020-02-28)
Novel therapies are urgently needed for ovarian cancer, the deadliest gynecologic malignancy. Ovarian cancer has thus far been refractory to immunotherapies that stimulate the host immune system to recognize and kill cancer cells. This may be because of a suppressive