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M-132

MSTFA Reagent

ampule of 10 × 1.2 mL, analytical standard, Cerilliant®

Synonym(s):

N-Methyl-N-(trimethylsilyl)trifluoroacetamide, N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA

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About This Item

Linear Formula:
CF3CON(CH3)Si(CH3)3
CAS Number:
24589-78-4
Molecular Weight:
199.25
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329817869
EC Number:
246-331-6
Beilstein/REAXYS Number:
1941550
MDL number:
MFCD00000411
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grade

analytical standard

Quality Segment

100

vapor density

>1 (vs air)

vapor pressure

8.8 mmHg ( 27 °C)

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

packaging

ampule of 10 × 1.2 mL

manufacturer/tradename

Cerilliant®

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.38 (lit.)

bp

130-132 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

application(s)

forensics and toxicology

format

neat

storage temp.

−20°C

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

General description

MSTFA (N-Methyl-N-trimethylsilylfluoroacetamide) is an important trimethylsilyl reagent, and a commonly applied reagent since it is highly reactive towards a broad range of compound classes. GC-MS optimization studies reveal the use of this reagent either alone or in combination with 1% of trimethylchlorosilane as a catalyst for silylation of complex mixtures. It has similar reactivity as BSA and BSTFA.

Application

MSTFA reagent may be used as a derivatizing agent in the following:
  • Analysis of estrogen steroids such as estrone (E1), 17α-ethinylestradiol (EE2), and trenbolone acetate metabolites, melengestrol in environmental matrices using gas chromatography coupled to mass spectrometry (GC-MS).
  • Quantification of ibuprofen, naproxen, ketoprofen, and diclofenac in wastewater samples using gas chromatography coupled to mass spectrometry (GC-MS).

Features and Benefits

  • Very volatile of TMS-acetamides.
  • More volatile than BSA or BSTFA but with similar silylation strength.
  • Useful in the analysis of volatile trace materials.
  • Used in the preparation of volatile and thermally stable derivatives for GC and MS analysis.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

77.0 °F - closed cup

flash_point_c

25 °C - closed cup

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