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5.05816

Xanomeline Oxalate

≥99% (HPLC), muscarinic acetylcholine receptor (mAChR) subtype M1 agonist, solid

Synonym(s):

Xanomeline Oxalate, 3-(hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole, Muscarinic Acetylcholine Receptor (mAChR) Agonist, Xanomeline

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About This Item

Empirical Formula (Hill Notation):
C14H23N3OS · xC2H2O4
CAS Number:
141064-23-5
Molecular Weight:
281.42 (free base basis)
MDL number:
MFCD12828778
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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Product Name

Xanomeline Oxalate,

assay

≥99% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 10 mM, ethanol: 25 mM

storage temp.

2-8°C

SMILES string

[s]1nc(c(n1)C2=CCCN(C2)C)OCCCCCC.OC(=O)C(=O)O

InChI

1S/C14H23N3OS.C2H2O4/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12;3-1(4)2(5)6/h8H,3-7,9-11H2,1-2H3;(H,3,4)(H,5,6)

InChI key

ZJOUESNWCLASJP-UHFFFAOYSA-N

General description

An agonist selective for muscarinic acetylcholine receptor (mAChR) subtype M1 (EC50 = 0.3, 5, 42, 52 and 92.5 nM at M1, M3, M5, M4 and M2 receptors respectively). An antipsychotic agent. Used in improving cognitive deficits and behavioral disturbances in Alzheimer′s disease and schizophrenia.

Other Notes

Wang, D., et al., 2011. Biochem. Biophys. Res. Commun.410, 229.
Si, W., et al., 2010. Neurosci. Lett.473, 115.
Stanhope, et al., 2001. J. Exp. Pharmacol. Ther.299, 782.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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