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Merck

87368

Tetrahydrofuran

≥99.9%, ACS reagent, contains ~0.025% 2, 6-di-tert-butyl-4-methylphenol as stabilizer, 250 ppm BHT as inhibitor, suitable for solid phase extraction (SPE), reag. Ph. Eur.

Synonym(s):

THF, Butylene oxide, Oxolane, Tetramethylene oxide

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About This Item

Empirical Formula (Hill Notation):
C4H8O
CAS Number:
109-99-9
Molecular Weight:
72.11
UNSPSC Code:
12352005
PubChem Substance ID:
329769580
EC Number:
203-726-8
Beilstein/REAXYS Number:
102391
MDL number:
MFCD00005356
Assay:
≥99.9%
Technique(s):
solid phase extraction (SPE): suitable
Bp:
65-67 °C (lit.)
Vapor pressure:
114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

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Product Name

Tetrahydrofuran, contains 250 ppm BHT as inhibitor, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.9%

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

SMILES string

C1CCOC1

grade

ACS reagent
puriss. p.a.

agency

reag. Ph. Eur.

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

autoignition temp.

610 °F

contains

250 ppm BHT as inhibitor
~0.025% 2,6-di-tert-butyl-4-methylphenol as stabilizer

expl. lim.

1.8-11.8 %

technique(s)

solid phase extraction (SPE): suitable

impurities

≤0.001% free acid (as CH3COOH)
≤0.005% peroxides (as H2O2)
≤0.05% water

evapn. residue

≤0.001%

refractive index

n20/D 1.407 (lit.)
n20/D 1.407

pH

~7

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

density

0.887 g/mL at 20 °C
0.889 g/mL at 25 °C (lit.)

cation traces

Al: ≤0.5 mg/kg
B: ≤0.02 mg/kg
Ba: ≤0.1 mg/kg
Bi: ≤0.1 mg/kg
Ca: ≤0.5 mg/kg
Cd: ≤0.05 mg/kg
Co: ≤0.02 mg/kg
Cr: ≤0.02 mg/kg
Cu: ≤0.02 mg/kg
Fe: ≤0.1 mg/kg
K: ≤0.5 mg/kg
Li: ≤0.1 mg/kg
Mg: ≤0.1 mg/kg
Mn: ≤0.02 mg/kg
Mo: ≤0.1 mg/kg
Na: ≤0.5 mg/kg
Ni: ≤0.02 mg/kg
Pb: ≤0.1 mg/kg
Sn: ≤0.1 mg/kg
Sr: ≤0.1 mg/kg
Zn: ≤0.1 mg/kg

Quality Level

200

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Analysis Note

miscible with water and ethanol (96%) pass

Application

Tetrahydrofuran has been used as a solvent for the preparation of sol-gel solution for coating solid phase microextraction (SPME) fibers in a study.

It may be used for the dissolution of poly-ε-caprolactone (PCL) and 1,3-diaminopentane, during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds and acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)- 1,3-diaminopentane (117) polymer, respectively.

General description

The product is tetrahydrofuran (THF) and it contains 250ppm BHT (Butylated hydroxytoluene) as an inhibitor. THF is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies. Butane-1,4-diol is formed as an intermediate during the synthesis of THF. Hot THF is useful for the dissolution of polyvinylidene chloride (PVDV).

Other Notes

Go to our Greener Alternative-2-Methyl Tetrahydrofuran - 155810

Go to our Greener Alternative-Cyclopentyl methylether - 675989
Sales restrictions may apply
The article number 87368-6X1L-M will be discontinued. Please order the single bottle 87368-1L-M which is physically identical with the same exact specifications.

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system, Respiratory system

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-6.2 °F - closed cup

flash_point_c

-21.2 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP1083
BCCN8669
BCCN2381
BCCM9333
BCCM7357

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Electrospun amino-functionalized PDMS as a novel SPME sorbent for the speciation of inorganic and organometallic arsenic species.
Boyaci E, et al.
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Todd J Harris et al.
Biomaterials, 31(5), 998-1006 (2009-10-24)
The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant concern is that the interior and
Haiying Yu et al.
Biomaterials, 30(4), 508-517 (2008-11-01)
Natural bone growth greatly depends on the precedent vascular network that supplies oxygen and essential nutrients and removes metabolites. Likewise, it is crucial for tissue-engineered bone to establish a vascular network that temporally precedes new bone formation, and spatially originates
Synthetic routes to tetrahydrofuran, tetrahydropyran, and spiroketal units of polyether antibiotics and a survey of spiroketals of other natural products.
Boivin TLB.
Tetrahedron, 43(15), 3309-3362 (1987)
Eagleson M.
Concise Encyclopedia Chemistry, 883-883 (1994)
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