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C5020

Cefazolin sodium salt

89.1-110.1%

Synonym(s):

Cefazoline sodium, Monosodium cefazolin

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About This Item

Empirical Formula (Hill Notation):
C14H13N8NaO4S3
CAS Number:
27164-46-1
Molecular Weight:
476.49
UNSPSC Code:
51282532
NACRES:
NA.76
PubChem Substance ID:
24278318
EC Number:
248-278-4
Beilstein/REAXYS Number:
3585038
MDL number:
MFCD00056883
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Quality Level

200

assay

89.1-110.1%

form

powder

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn4cnnn4)C3=O)C([O-])=O)s1

InChI

1S/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1/t9-,12-;/m1./s1

InChI key

FLKYBGKDCCEQQM-WYUVZMMLSA-M

General description

Chemical structure: β-lactam

Biochem/physiol Actions

Used to study the effect of expression, binding and inhibition of penicillin-binding proteins, especially PBP2 and PBP4 on bacterial cell wall mucopeptide synthesis.

Preparation Note

Freely soluble in water, very slightly soluble in chloroform and ethanol.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000519634
0000519634
0000521827
0000521827
0000492391

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Mei Zhang et al.
Therapeutic drug monitoring, 40(6), 682-692 (2018-07-18)
Pharmacokinetic studies and therapeutic drug monitoring of antibiotics require a simple, rapid, and reliable analytical method for monitoring the concentrations in plasma, including unbound concentrations for highly protein-bound drugs. The aim of the current work was to develop and validate
Bo-Bae Seo et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 106(2), 751-759 (2017-03-24)
An injectable hydrogel system with sustained bone morphogenetic protein 2 (BMP-2) release ability was developed for vertical bone regeneration at peri-implant sites and enhanced osseointegration of dental implants. In three young male beagle dogs, a pair of defects was created
Francesca D'Este et al.
Journal of peptide science : an official publication of the European Peptide Society, 23(10), 777-789 (2017-07-15)
The prevention of implant-associated infection, one the most feared complications in orthopaedic surgery, remains a major clinical challenge and urges development of effective methods to prevent bacterial colonization of implanted devices. Alpha-helical antimicrobial peptides (AMPs) may be promising candidates in
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