C5743
Cilastatin sodium salt
powder, ≥98% (HPLC)
Synonym(s):
Cilastatin sodium
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About This Item
Empirical Formula (Hill Notation):
C16H25N2NaO5S
CAS Number:
Molecular Weight:
380.43
MDL number:
UNSPSC Code:
12352204
EC Number:
279-694-4
NACRES:
NA.77
Product Name
Cilastatin sodium salt, ≥98% (HPLC)
biological source
synthetic (organic)
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
water: 10 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
SMILES string
[Na+].S(C[C@H](N)C(=O)[O-])CCCC\C=C(/NC(=O)[C@@H]1C(C1)(C)C)\C(=O)O
InChI
1S/C16H26N2O5S.Na/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);/q;+1/p-1/b12-6-;/t10-,11+;/m1./s1
InChI key
QXPBTTUOVWMPJN-QBNHLFMHSA-M
General description
Cilastatin sodium salt is off-white to yellowish-white, hygroscopic, amorphous compound. It is derivatized from heptenoic acid. Its molecular mass is 380.43 g.
Biochem/physiol Actions
Inhibitor of dehydropeptidase I
Inhibitor of the renal enzyme dehydropeptidase I and some bacterial zinc-containing β-lactamases. By these action, cilastatin suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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First-order derivative ultraviolet spectrophotometry of imipenem-cilastatin formulations.
Tabbouche OS and Soukkariyyeh I
Journal of Taibah University Medical Sciences, 9(3), 178-181 (2014)
Jinkyung Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(9) (2022-02-25)
Aminoglycosides (AGs) are commonly used antibiotics that cause deafness through the irreversible loss of cochlear sensory hair cells (HCs). How AGs enter the cochlea and then target HCs remains unresolved. Here, we performed time-lapse multicellular imaging of cochlea in live
Saurav Roy Choudhury et al.
Cell, 178(5), 1205-1221 (2019-08-24)
A hallmark feature of inflammation is the orchestrated recruitment of neutrophils from the bloodstream into inflamed tissue. Although selectins and integrins mediate recruitment in many tissues, they have a minimal role in the lungs and liver. Exploiting an unbiased in vivo