C8890
4-Chloro-1-naphthol
horseradish peroxidase substrate, fluorogenic, ≥98% (GC), crystalline
Synonym(s):
4-chloronaphthalen-1-ol
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About This Item
Linear Formula:
ClC10H6OH
CAS Number:
Molecular Weight:
178.61
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
210-068-5
MDL number:
Beilstein/REAXYS Number:
509750
Product Name
4-Chloro-1-naphthol, crystalline
assay
≥98% (GC)
Quality Level
form
crystalline
mp
118-121 °C (lit.)
solubility
acetone: 50 mg/mL, clear, colorless to very faintly brown
storage temp.
−20°C
SMILES string
Oc1ccc(Cl)c2ccccc12
InChI
1S/C10H7ClO/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6,12H
InChI key
LVSPDZAGCBEQAV-UHFFFAOYSA-N
General description
Chromogenic peroxidase substrate useful in enzyme-linked detection procedures.
Application
4-Chloro-1-naphthol has been used to visualize protein bands in western blotting. It has also been used in staining polyvinylidene fluoride (PVDF) membrane by Nakane method.
Biochem/physiol Actions
4-Chloro-1-naphthol serves as a substrate for horseradish peroxidase.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Limited proteolysis of fibrinogen by fibrinogenase from Echis multisquamatis venom
Chernyshenko VO
The Protein Journal, 34(2), 130-134 (2015)
Endothelial microparticles induce formation of platelet aggregates via a von Willebrand factor/ristocetin dependent pathway, rendering them resistant to dissociation
JIMENEZ JJ, et al.
Journal of Thrombosis and Haemostasis, 3(6), 1301-1308 (2005)
J M Elias
American journal of clinical pathology, 73(6), 797-799 (1980-06-01)
The substitution of 4-chloro-1-naphthol for benzidine-containing compounds used in the myeloperoxidase stain for distinguishing granulocytes from lymphoid blood elements is described. 4-Chloro-1-naphthol is an acceptable substitute for benzidine compounds, which are considered to be carcinogenic. The feasibility of using this