D4268
NG,NG-Dimethylarginine dihydrochloride
≥98% (TLC), powder, NOS inhibitor
Synonym(s):
asym-Dimethylarginine, ADMA
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About This Item
Empirical Formula (Hill Notation):
C8H18N4O2 · 2HCl
CAS Number:
Molecular Weight:
275.18
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
powder
Product Name
NG,NG-Dimethylarginine dihydrochloride,
assay
≥98% (TLC)
Quality Segment
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
room temp
SMILES string
Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O
InChI
1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
InChI key
SYLNVYJOPZWPJI-ILKKLZGPSA-N
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
General description
NG,NG-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).
Application
NG,NG- Dimethylarginine dihydrochloride has been used:
- to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
- as a standard for measuring L-arginine and dimethylarginines
- to study its effects on hepatic deterioration
Biochem/physiol Actions
Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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