F3922
Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-FGFR-3
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p), WB
Citations:
4
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~120 kDa
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using protease-digested, human and animal tissue sections, western blot: 1:500 using extract of FGFR-3 transfected cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FGFR3(2261)
General description
FGFR3 (fibroblast growth factor receptor 3) is widely expressed in many fetal and adult human and animal tissues. It belongs to the fibroblast growth factor receptor (Fgfr) family of proteins. It has 19 exons, an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. It is located on human chromosome 4p16.3.
Immunogen
synthetic peptide corresponding to amino acids 359-372 of the extracellular region of human fibroblast growth factor receptor-3.
Application
Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit has been used in:
- immunoblotting
- immunohistochemistry
- immunoprecipitation
Biochem/physiol Actions
Fibroblast growth factors (FGFs) are substantially involved in normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, and in hematopoiesis as well as in tissue remodeling and maintenance. They have also been implicated in pathological conditions such as tumorigenesis and metastasis. Deletions of chromosome 4p encompassing the FGFR3 (fibroblast growth factor receptor 3) gene cause the Wolf-Hirschhorn syndrome (growth failure, mental retardation, cardiac and bone malformations). Achondroplasia is an inherited disorder in which growth abnormality of bone or cartilage lead to skeletal maldevelopment and dwarfism. It is associated with recurrent mutations of a single amino acid in the transmembrane domain of the FGFR-3 protein.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Preparation Note
Affinity isolated on a peptide-agarose column.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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flash_point_f
Not applicable
flash_point_c
Not applicable
Storage Class
12 - Non Combustible Liquids
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Related Content
Instructions
Loss of heterozygosity at 4p16. 3 and mutation of FGFR3 in transitional cell carcinoma
Sibley K, et al.
Oncogene, 20(6), 686-686 (2001)
Exploring the developmental mechanisms underlying Wolf-Hirschhorn Syndrome: Evidence for defects in neural crest cell migration
Rutherford EL and Lowery LA
Developmental Biology, 420(1), 1-10 (2016)
Fibroblast growth factors: biology, function, and application for tissue regeneration
Yun YR, et al.
Journal of Tissue Engineering, 1(1), 218142-218142 (2010)