F7930
FGFR3 (397-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
Eph receptor tyrosine kinase, growth hormone receptor, ACH, CD333, CEK2, HSFGFR3EX, JTK4
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About This Item
NACRES:
NA.32
UNSPSC Code:
51111800
Form:
buffered aqueous glycerol solution
Assay:
≥70% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells
Mol wt:
~73 kDa
biological source
human
Quality Level
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
95-129 nmol/min·mg
mol wt
~73 kDa
packaging
pkg of 10 μg
technique(s)
cell based assay: suitable
solubility
water: soluble
Protein ID accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... FGFR3(2261)
General description
Research area: Cancer
FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.FGFR3 has a strong affinity for canonical FGF ligands.
FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.FGFR3 has a strong affinity for canonical FGF ligands.
Biochem/physiol Actions
FGFR3 (fibroblast growth factor receptor 3) plays an essential role in the signaling pathways during embryogenesis and angiogenesis. This gene is either mutated or up-regulated in multiple myeloma, cervical carcinoma and nonmuscle-invasive urothelial carcinoma (UC) of the bladder.Apart from this, certain mutations in FGFR3 are also known to be linked with skeletal disorders such as various forms of dwarfism. FGFR3 also plays hepatoprotective function during liver damage.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Related Content
Instructions
FGFR3 biology and skeletal disease
Jyoti Narayana and William A Horton
Connective tissue research, 56(6), 427-433 (2015)
Corine G M L'Hôte et al.
Experimental cell research, 304(2), 417-431 (2005-03-08)
FGFR3 is a receptor tyrosine kinase (RTK) of the FGF receptor family, known to have a negative regulatory effect on long bone growth. Fgfr3 knockout mice display longer bones and, accordingly, most germline-activating mutations in man are associated with dwarfism.
Hiroko Tamagaki et al.
Biochemistry, 53(30), 5000-5007 (2014-07-11)
Activation of the protein tyrosine kinase receptors requires the coupling of ligand binding to a change in both the proximity and orientation of the single transmembrane (TM) helices of receptor monomers to allow transphosphorylation of the receptor kinase domain. We