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M1275

Naproxen sodium

Name: Naproxen sodium
Brand: SIGMA

synthetic (organic), 98.0-102.0%, Prostaglandin H synthase 1 and 2 inhibitor, powder

Synonym(s):

(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₃NaO₃

CAS Number:

26159-34-2

Molecular Weight:

252.24

NACRES:

NA.77

PubChem Substance ID:

57654352

UNSPSC Code:

12352200

EC Number:

247-486-2

MDL number:

MFCD00058507

Assay:

98.0-102.0%

Form:

powder

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Properties

Product Name

Naproxen sodium, 98.0-102.0%

biological source

synthetic (organic)

Quality Segment

200

assay

98.0-102.0%

form

powder

solubility

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

originator

Bayer

SMILES string

[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O

InChI

1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

InChI key

CDBRNDSHEYLDJV-FVGYRXGTSA-M

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Description

General description

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).

Application

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin. It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.

Biochem/physiol Actions

Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.