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Merck

P5188

TWEEN® 80

Molecular Biology, syrup

Synonym(s):

POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80

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About This Item

CAS Number:
9005-65-6
UNSPSC Code:
12161900
NACRES:
NA.21
MDL number:
MFCD00082107

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InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

SMILES string

CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO

InChI key

RGPBUVUVZKQNHD-MDZDMXLPSA-N

grade

Molecular Biology

description

non-ionic

form

syrup

Quality Level

200

composition

Oleic acid, ≥58.0% (balance primarily linoleic, palmitic, and stearic acids)

CMC

0.012 mM

transition temp

cloud point 65 °C

density

1.06 g/mL at 25 °C

HLB

15

suitability

molecular biology tested

foreign activity

DNAse (Exonuclease Detection), NICKase (Endonuclease Detection), RNAse, none detected

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General description

TWEEN 80 is a polyethylene sorbitol ester and has a molecular weight of 1.31 kDa. It is useful as a stabilizer and emulsifier commercially. It is known to be used in ice-cream for its drying property.

Application

Non-ionic detergent used for selective protein extraction and isolation of nuclei from mammalian cell lines.

Legal Information

TWEEN is a registered trademark of Croda International PLC

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

>235.4 °F - closed cup

flash_point_c

> 113 °C - closed cup

ppe

Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ4440
MKCX1890
MKCQ4401
MKCH7978
MKCF0641

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Ice Cream, 86-86 (2003)
Fats in Food Technology (2014)
Wei-Ju Chung et al.
Journal of biological physics, 43(4), 511-524 (2017-09-10)
DNA samples are commonly frozen for storage. However, freezing can compromise the integrity of DNA molecules. Considering the wide applications of DNA molecules in nanotechnology, changes to DNA integrity at the molecular level may cause undesirable outcomes. However, the effects
Sara Moufarrij et al.
Scientific reports, 10(1), 3470-3470 (2020-02-28)
Novel therapies are urgently needed for ovarian cancer, the deadliest gynecologic malignancy. Ovarian cancer has thus far been refractory to immunotherapies that stimulate the host immune system to recognize and kill cancer cells. This may be because of a suppressive
Yun Xia et al.
Cell, 175(4), 1059-1073 (2018-10-03)
Motivated by the clinical observation that interruption of the mevalonate pathway stimulates immune responses, we hypothesized that this pathway may function as a druggable target for vaccine adjuvant discovery. We found that lipophilic statin drugs and rationally designed bisphosphonates that
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Product Information Sheet - P5188

Product Information Sheet

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