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SML0038

Fluvastatin sodium hydrate

Name: Fluvastatin sodium hydrate
Brand: SIGMA

≥98% (HPLC), HMG-CoA reductase inhibitor, powder

Synonym(s):

(±)-(3R^*,5S^*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₅FNO₄ · Na · xH₂O

CAS Number:

93957-55-2

Molecular Weight:

433.45 (anhydrous basis)

UNSPSC Code:

12352204

PubChem Substance ID:

329825108

NACRES:

NA.77

MDL number:

MFCD20488050

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

Fluvastatin sodium hydrate, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

H₂O: ≥9 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

O.[Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13

InChI

1S/C24H26FNO4.Na.H2O/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);;1H2/q;+1;/p-1/b12-11+;;/t18-,19-;;/m1../s1

InChI key

KKEMYLLTGGQWCE-PMRANXHDSA-M

Description

Application

Fluvastatin sodium hydrate has been used:

to examine its effect on β -glucan-induced training on immunity
to investigate the effect of statins on the number of uncoupling protein 1 (UCP1)⁺ cells
to determine its effect on insulin degrading enzyme (IDE) secretion from astrocytes
to treat and study its effect on human umbilical vein endothelial cells (HUVECs) in vitro

Fluvastatin sodium hydrate has been used:

to test its anti-hepatitis C virus (HCV) activity
as a cholesterol inhibitor
to study its effects on β-glucan-induced monocyte immune training

Biochem/physiol Actions

Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

Fluvastatin has antifungal activity.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c