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Merck

SML1394

Olmesartan

≥98% (HPLC), Angiotensin II Type I receptor blocker, powder

Synonym(s):

4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid, Olmesartan acid

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About This Item

Empirical Formula (Hill Notation):
C24H26N6O3
CAS Number:
144689-24-7
Molecular Weight:
446.50
UNSPSC Code:
12352200
PubChem Substance ID:
329825842
NACRES:
NA.77
MDL number:
MFCD09749896
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Product Name

Olmesartan, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(C)(C)C1=C(C(O)=O)N(CC2=CC=C(C3=C(C4=NNN=N4)C=CC=C3)C=C2)C(CCC)=N1

InChI

1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)

InChI key

VTRAEEWXHOVJFV-UHFFFAOYSA-N

Gene Information

human ... AGTR1(185)

Related Categories

Application

Olmesartan has been used as an angiotensin II receptor 1 (AT1) receptor inhibitor to study the effect of angiotensin II type 1 receptor interactions in the regulation of renal afferent arterioles in angiotensin II-dependent hypertension.

Biochem/physiol Actions

Olmesartan is an Angiotensin II Type I receptor blocker.
Olmesartan is an Angiotensin II Type I receptor blocker. Olmesartan is the active form of the antihypertensive drug olmesartan medoxomil.
Olmesartan possesses anti-inflammatory and anti-oxidative stress properties. It protects neuronal cells against oligomerized amyloid β (Aβ)-induced cellular senescence.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000390400
0000381193
0000381193
0000390400
0000249586

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Ferrán Catalá-López et al.
PLoS medicine, 13(3), e1001971-e1001971 (2016-03-10)
Medications aimed at inhibiting the renin-angiotensin system (RAS) have been used extensively for preventing cardiovascular and renal complications in patients with diabetes, but data that compare their clinical effectiveness are limited. We aimed to compare the effects of classes of
Ariadne M Brondi et al.
Journal of analytical methods in chemistry, 2017, 4878316-4878316 (2018-02-03)
A study was carried out to investigate compatibility of amlodipine besylate and olmesartan medoxomil with a variety of pharmaceutical excipients. Both drugs are antihypertensive agents that can be administered alone, in monotherapy, or in pharmaceutical association. The studies were performed
Malek M Aziz et al.
Canadian journal of physiology and pharmacology, 98(4), 183-193 (2019-10-31)
Doxorubicin (DOX), an anthracycline antibiotic, is an important antineoplastic agent due to its high antitumor efficacy in hematological as well as in solid malignancies. The clinical use of DOX is limited due to its cardiotoxic effects. The present study aimed
Jian Wang et al.
ACS chemical neuroscience, 12(7), 1162-1169 (2021-03-13)
Alzheimer's disease (AD) is a neurodegenerative disease with high morbidity. The deposition of oligomerized amyloid β (Aβ) is the pathological feature of AD. The Aβ-caused neuronal oxidative stress and cellular senescence play an important role in the development and progression
Haiyi Chen et al.
ACS chemical neuroscience, 10(1), 677-689 (2018-09-29)
The number of solved G-protein-coupled receptor (GPCR) crystal structures has expanded rapidly, but most GPCR structures remain unsolved. Therefore, computational techniques, such as homology modeling, have been widely used to produce the theoretical structures of various GPCRs for structure-based drug
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