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557404-M

RNA Polymerase III Inhibitor

InSolution, ≥97%

Synonym(s):

InSolution RNA Polymerase III Inhibitor, 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide, N-(1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl))-2-chlorobenzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C19H15Cl2N3O2S2
CAS Number:
577784-91-9
Molecular Weight:
452.38
MDL number:
MFCD00112663
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
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Quality Level

100

assay

≥97% (HPLC)

form

liquid

potency

27 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage temp.

−70°C

SMILES string

[S](=O)(=O)(Nc2[n](nc(c2)c3[s]c4c(c3C)cc(cc4)Cl)C)c1c(cccc1)Cl

InChI

1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3

InChI key

BVBDTTLISMIOJY-UHFFFAOYSA-N

General description

A cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. The solid form of this compound (Cat. No. 557403) is also available.

Biochem/physiol Actions

Primary Target
RNA Polymerase III

Physical form

A 25 mM (5 mg/442 µL) solution of RNA Polymerase III Inhibitor (Cat. No. 557403) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Other Notes

Wu, L., et al. 2003. Euk. Cell2, 256.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup - (refers to pure substance)

flash_point_c

87 °C - closed cup - (refers to pure substance)

Certificates of Analysis (COA)

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