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F6300

Flumazenil

Name: Flumazenil
Brand: SIGMA

>99% (HPLC), solid, benzodiazepine receptor antagonist

Synonym(s):

Ro 15-1788, Ro15-1788

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₄FN₃O₃

CAS Number:

78755-81-4

Molecular Weight:

303.29

UNSPSC Code:

12352200

PubChem Substance ID:

24278437

NACRES:

NA.77

MDL number:

MFCD00242764

Assay:

>99% (HPLC)

Form:

solid

Quality level:

100

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Properties

Product Name

Flumazenil, >99% (HPLC), solid

Quality Level

100

assay

>99% (HPLC)

form

solid

color

white

originator

Roche

storage temp.

2-8°C

SMILES string

CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(F)ccc-23

InChI

1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3

InChI key

OFBIFZUFASYYRE-UHFFFAOYSA-N

Gene Information

human ... BZRAP1(9256), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)
rat ... Gabra2(29706), Gabrg1(140674)

Description

General description

Flumazenil reverses sedative and hypnotic effects of benzodiazepines. It is used to increase acquisition, enhance retention and treat amnesia in mice.

Biochem/physiol Actions

Highly specific benzodiazepine receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Effect of flumazenil on memory retrieval determined by trial-to-criteria inhibitory avoidance method in mice

Raut SB, et al.

Journal of Pharmacology & Pharmacotherapeutics, 7(1), 24-24 (2016)

Grey matter density and GABAA binding potential show a positive linear relationship across cortical regions.

N W Duncan et al.

Neuroscience, 235, 226-231 (2013-02-06)

Voxel based morphometry (VBM) is a widely used technique for studying the structure of the brain. Direct comparisons between the results obtained using VBM and the underlying histology are limited, however. To circumvent the problems inherent in comparing VBM data

Flumazenil--treatment or toxin.

Donna L Seger

Journal of toxicology. Clinical toxicology, 42(2), 209-216 (2004-06-25)

Flumazenil is frequently administered to the poisoned patient. Seizures may be precipitated and resedation may occur in patients who awakened following flumazenil administration. Seizures may increase morbidity and mortality of the overdose. Benefit:Risk ratio of administering flumazenil should be determined

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