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Merck

112976

2,5-Di-tert-butylhydroquinone

99%

Synonym(s):

1,4-Dihydroxy-2,5-di-tert-butylbenzene, 2,5-Bis(1,1-dimethylethyl)-1,4-benzenediol, 2,5-Di-tert-butyl-1,4-benzenediol, 2,5-Di-tert-butyl-1,4-benzohydroquinone, 2,5-Di-tert-butyl-1,4-dihydroxybenzene, 2,5-Di-tert-butylquinol, 2,5-Dihydroxy-1,4-di-tert-butylbenzene, 2,5-Ditert-butylbenzene-1,4-diol, 3,6-Di-tert-butylhydroquinone

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About This Item

Linear Formula:
[(CH3)3C]2C6H2-1,4-(OH)2
CAS Number:
Molecular Weight:
222.32
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
201-841-8
Beilstein/REAXYS Number:
2049542
MDL number:
Assay:
99%
Form:
solid
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Product Name

2,5-Di-tert-butylhydroquinone, 99%

InChI key

JZODKRWQWUWGCD-UHFFFAOYSA-N

InChI

1S/C14H22O2/c1-13(2,3)9-7-12(16)10(8-11(9)15)14(4,5)6/h7-8,15-16H,1-6H3

SMILES string

CC(C)(C)c1cc(O)c(cc1O)C(C)(C)C

assay

99%

form

solid

autoignition temp.

790 °F

mp

216-218 °C (lit.)

Quality Level

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Application

2,5-Di-tert-butylhydroquinone is the oxidation substrate used to measure the catalytic activity of the copper(II) enzyme-like catalysts.

Biochem/physiol Actions

2,5-Di-tert-butylhydroquinone specifically inhibits the sarcoplasmic reticulum (SR) Ca2+ uptake in the rat ventricle.
Blocks calcium-dependent insulin signaling in human beta cells

pictograms

Skull and crossbonesEnvironment

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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A A Kabbara et al.
The American journal of physiology, 272(2 Pt 2), H1001-H1010 (1997-02-01)
The effects of 2,5-di-tert-butylhydroquinone (TBQ) on cardiac muscle contractility were investigated using cardiac preparations from the right ventricle of the rat. In saponin-skinned preparations, TBQ (50 and 100 microM) did not significantly affect the maximal isometric Ca2+-activated force or the
Salvatore Nesci et al.
Biochimie, 140, 73-81 (2017-06-28)
The mitochondrial F-ATPase can be activated either by the classical cofactor Mg
Pedro C Redondo et al.
Biochimica et biophysica acta, 1783(6), 1163-1176 (2008-01-15)
Endogenously expressed human canonical transient receptor potential 1 (hTRPC1) and human canonical transient receptor potential 6 (hTRPC6) have been shown to play a role in store-operated Ca2+ entry (SOCE) in human platelets, where two mechanisms for SOCE, regulated by the
Markus Keller et al.
Cardiovascular research, 74(1), 39-45 (2007-03-06)
Cellular Ca(2+) waves are understood as reaction-diffusion systems sustained by Ca(2+)-induced Ca(2+) release (CICR) from Ca(2+) stores. Given the recently discovered sensitization of Ca(2+) release channels (ryanodine receptors; RyRs) of the sarcoplasmic reticulum (SR) by luminal SR Ca(2+), waves could
Joel Castro et al.
The Biochemical journal, 418(3), 553-566 (2008-11-15)
The question of whether the activation of SOCs (store-operated Ca(2+) channels) requires the whole or part of the ER (endoplasmic reticulum) has not been fully resolved. The role of a putative sub-compartment of the ER in SOC activation in liver

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