202509
Poly(ethylene glycol) methyl ether
average Mn 2,000, methoxy, hydroxyl
Synonym(s):
Polyethylene glycol, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG
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About This Item
Linear Formula:
CH3(OCH2CH2)nOH
CAS Number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
MDL number:
Product Name
Poly(ethylene glycol) methyl ether, average Mn ~2,000
SMILES string
O(CCO)C
InChI
1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
InChI key
XNWFRZJHXBZDAG-UHFFFAOYSA-N
vapor density
>1 (vs air)
vapor pressure
0.05 mmHg ( 20 °C)
form
flakes (or pellets)
mol wt
average Mn ~2,000
viscosity
54.6 cSt(210 °F)(lit.)
transition temp
Tm 52 °C
functional group
hydroxyl
Quality Level
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Application
Poly(ethylene glycol) methyl ether-attached dendrimers can be used as carriers for anticancer drugs. This novel drug carrier has a biocompatible surface and an interior for the encapsulation of drugs.
It can be used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.
It can also be used as a starting material in the preparation of a biodegradable amphiphilic copolymer of poly(L-alanine) with mPEG.
It can be used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.
It can also be used as a starting material in the preparation of a biodegradable amphiphilic copolymer of poly(L-alanine) with mPEG.
Features and Benefits
Inserting poly(ethylene glycol) methyl ether (mPEG) side chain enhances the hydrophilicity and flexibility of the polymer matrix.
General description
It is a Polyethylene glycol (PEG) macromer with a reactive chain end consisting of methyl ether. Etherification of the PEG chain ends can be undertaken in basic conditions by reacting it with alkyl halides. mPEG can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
359.6 °F - closed cup
flash_point_c
182 °C - closed cup
ppe
Eyeshields, Gloves
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Yiyi Yu et al.
Journal of pharmaceutical sciences, 102(3), 1054-1062 (2013-01-03)
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in
Lina Du et al.
Anti-cancer drugs, 24(2), 172-180 (2012-09-20)
A functionalized poly(amidoamine) (PAMAM) nanocarrier was designed and prepared to deliver anticancer drugs. The nanocarrier is a copolymer with a core-shell structure with 3.0 G PAMAM as the core and sequentially conjugated poly(2-(N,N-diethylamino)ethyl methacrylate) (pDEA) and methoxy-poly(ethylene glycol) 2000 (mPEG)
Mulu Z Tesfay et al.
Journal of virology, 87(7), 3752-3759 (2013-01-18)
We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized in the bone marrow. One of the presumed advantages for using VSV as an oncolytic
Pengxiang Zhao et al.
Chemical communications (Cambridge, England), 49(31), 3218-3220 (2013-03-14)
"Click" chemistry now offers access to a great variety of triazoles, and the first example of a strategy to stabilize gold nanoparticles (AuNPs) with a new 1,2,3-triazole-mPEG ligand is developed here together with preliminary examples of possible applications.
Seung-Young Lee et al.
Biomaterials, 34(2), 552-561 (2012-10-20)
Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier
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