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Merck

A79604

4-Aminosalicylic acid

99%, for peptide synthesis

Synonym(s):

4-Amino-2-hydroxybenzoic acid, PAS

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About This Item

Linear Formula:
H2NC6H3-2-(OH)CO2H
CAS Number:
65-49-6
Molecular Weight:
153.14
NACRES:
NA.22
PubChem Substance ID:
24891299
UNSPSC Code:
12352106
EC Number:
200-613-5
MDL number:
MFCD00007789
Beilstein/REAXYS Number:
473071

Product Name

4-Aminosalicylic acid, 99%

InChI key

WUBBRNOQWQTFEX-UHFFFAOYSA-N

InChI

1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)

SMILES string

Nc1ccc(C(O)=O)c(O)c1

assay

99%

form

powder

reaction suitability

reaction type: solution phase peptide synthesis

color

white to beige

mp

135-145 °C (lit.)

application(s)

peptide synthesis

Quality Level

200

Gene Information

human ... PTPN1(5770)

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Application

4-Aminosalicylic acid (4-ASA) can be used in the synthesis of:
  • Azo derivatives of 4-ASA with anti-inflammatory effects.
  • Ammonium 4-aminosalicylate salt polymorphs which are used as pharmaceutical ingredients.
  • Salicylic acid-triazole analogs which are used as quorum sensing inhibitors against Pseudomonas aeruginosa.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL6747
BCCF7304
BCCD3897
BCCC1939
BCBZ8103

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Design, Synthesis and Biological Evaluation of Triazole-Containing 2-Phenylindole and Salicylic Acid as Quorum Sensing Inhibitors Against Pseudomonas aeruginosa.
Srinivasarao S, et al.
ChemistrySelect, 3(32), 9170-9180 (2018)
Polymorphic ammonium salts of the antibiotic 4-aminosalicylic acid.
Andre V, et al.
Crystal Growth & Design, 12(6), 3082-3090 (2012)
Maria João Forjaz et al.
Movement disorders : official journal of the Movement Disorder Society, 30(4), 545-551 (2014-12-30)
The Parkinson Anxiety Scale is a new scale developed to measure anxiety severity in Parkinson's disease specifically. It consists of three dimensions: persistent anxiety, episodic anxiety, and avoidance behavior. This study aimed to assess the measurement properties of the scale
Synthesis of azo derivatives of 4-aminosalicylic acid.
Zhao ZB, et al.
Chinese Chemical Letters = Zhongguo Hua Xue Kuai Bao, 18(6), 639-642 (2007)
Joan Cid et al.
Platelets, 26(2), 190-194 (2014-05-29)
Platelet refractoriness (PR) due to HLA alloimmunization is a common and serious complication of patients receiving long-term packed red blood cell and platelet transfusions. Although most alloimmunized patients will respond to HLA-matched platelets, 20-50% of patients will remain refractory even
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