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Merck

676950-M

Veratridine

≥98% (TLC), solid, Na⁺ channel opener, Calbiochem

Synonym(s):

Veratridine

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About This Item

Empirical Formula (Hill Notation):
C36H51NO11
CAS Number:
71-62-5
Molecular Weight:
673.79
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00082515
Assay:
≥98% (TLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze

Key Documents

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Product Name

Veratridine, A Na+ channel opener.

SMILES string

N21[C@H]([C@]([C@@]3([C@H]([C@]4([C@]([C@H]5[C@]6(O[C@]7([C@H]([C@@]6(CC[C@@H]7OC(=O)c8cc(c(cc8)OC)OC)C)CC5)O)C4)(C[C@@H]3O)O)O)C2)O)(O)C)CC[C@@H](C1)C

InChI

1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1

InChI key

FVECELJHCSPHKY-YFUMOZOISA-N

description

Merck USA index - 14, 9954

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to yellow

solubility

DMSO: 25 mg/mL
ethanol: 25 mg/mL

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Primary Target
Na+ channel

Disclaimer

Toxicity: Highly Toxic (H)

General description

A Na+ channel opener. Increases intracellular Ca2+ levels without affecting Na+ - Ca2+ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na+ channels causing persistent activation. Induces cell death in bovine chromaffin cells.

Other Notes

Maroto, R., et al. 1994. Eur. J. Pharmacol. 270, 331.
Plattner, H., et al. 1994. J. Membr. Biol. 142, 229.
Rando, T.A., et al. 1989. J. Gen. Physiol.93, 43.
Rando, T.A., et al. 1986. Mol. Pharmacol.29, 467.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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