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Merck

HCCB4MAG-58K

MILLIPLEX® Human Circulating Cancer Biomarker Panel

Configurable Human Circulating Cancer Biomarker 10-Plex Panel 4

Synonym(s):

Luminex human circulating cancer biomarkers multiplex assay, Millipore human circulating cancer biomarkers multiplex kit, human cancer biomarker immunoassay panel

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000
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Quality Level

species reactivity

human

assay range

accuracy: 80-110%, standard curve range: 0.1-100 ng/mL
(L1CAM), standard curve range: 0.1-100 ng/mL
(Mesothelin), standard curve range: 0.3-250 ng/mL
(Hepsin), standard curve range: 1.4-1,000 ng/mL
(CD44), standard curve range: 1.4-1,000 ng/mL
(Transglutaminase 2 (TGM2)), standard curve range: 13.7-10,000 pg/mL
(EpCAM), standard curve range: 13.7-10,000 pg/mL
(Midkine), standard curve range: 2.7-2,000 ng/mL
(ALDH1A1), standard curve range: 20.6-15,000 pg/mL
(Carbonic Anhydrase IX (CA9)), standard curve range: 27.4-20,000 pg/mL
(Kallekrein-6), inter-assay cv: <10%
intra-assay cv: <20%

technique(s)

multiplexing: suitable

input

serum plasma (Cell culture, cell culture supernatants)

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

General description

Circulating cancer biomarkers give insight beyond intracellular oncogenesis and into how the body responds to the presence of a tumor, the dysregulation of homeostasis, and the relationship between a tumor and its environment. Multianalyte panels have become essential tools that enable researchers to measure cancer biomarkers simultaneously, teasing out these relationships and applying them to understand tumor biology.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 10 analytes in human serum, plasma, and cell culture supernatants.

Analytes included: Aldheyde dehydrogenase 1 Family, Member A1 (ALDH1A1), Carbonic Anhydrase IX (CA9), CD44, Epithelial cell adhesion molecule (EpCAM), Hepsin, Kallikrein-6, Mesothelin, Midkine, Neural cell adhesion Molecule L1 (L1CAM), Transglutaminase 2 (TGM2)

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

  • Versatile 10-Plex Analyte Kit: This panel allows for the simultaneous quantification of ten significant biomarkers, including ALDH1A1, CA9, and CD44, providing a broad scope for cancer research.
  • Diverse Sample Compatibility: Suitable for human serum, plasma, and tissue culture supernatants, allowing flexibility in sample types for various research applications.
  • Recommended Sample Dilution: The assay suggests using 25 μL of 1:5 diluted serum or plasma, with tissue culture supernatants requiring appropriate dilution, simplifying the preparation process.
  • Comprehensive Insights into Tumor Dynamics: By enabling the simultaneous measurement of multiple circulating biomarkers, this panel aids researchers in exploring the complex interactions between tumors and their microenvironment.
  • Increased Efficiency in Research: The multiplex capability allows for a significant boost in sample throughput, enabling researchers to analyze a larger number of samples in less time, which is crucial for high-volume research.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

wgk

WGK 3


Certificates of Analysis (COA)

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Imad Tarhoni et al.
Journal of immunoassay & immunochemistry, 39(1), 84-98 (2018-01-09)
Angiogenesis is associated with tumor progression in a range of malignancies. Herein, we develop custom immunobead assays for several mechanistically important targets and evaluated these against sera from cohorts of non-small cell lung cancer (NSCLC) patients. Antigen "capture" antibodies for

Global Trade Item Number

SKUGTIN
HCCB4MAG-58K-0704055977330878
HCCB4MAG-58K-0204055977330892
HCCB4MAG-58K-0804055977330861
HCCB4MAG-58K-0604055977330755
HCCB4MAG-58K-0904055977330847
HCCB4MAG-58K-0104055977330854
HCCB4MAG-58K-1004055977330830
HCCB4MAG-58K-0504055977330762
HCCB4MAG-58K-0404055977330779
HCCB4MAG-58K-0304055977330786

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