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Merck

10107409001

Roche

Mitomycin C

crystalline powder, 98%, pkg of 2 mg

Synonym(s):

Mitomycin C

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About This Item

Empirical Formula (Hill Notation):
C15H18N4O5
CAS Number:
50-07-7
Molecular Weight:
334.33
MDL number:
MFCD00078109
UNSPSC Code:
12352207
NACRES:
NA.54

Product Name

Mitomycin C, crystalline powder, 98%, pkg of 2 mg

SMILES string

N21[C@]([C@H]4N[C@H]4C2)([C@@H](C3=C1C(=O)C(=C(C3=O)N)C)COC(=O)N)OC

InChI

1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1

InChI key

NWIBSHFKIJFRCO-WUDYKRTCSA-N

assay

98%

form

crystalline powder

mol wt

334.3

packaging

pkg of 2 mg

manufacturer/tradename

Roche

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

Quality Level

100

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Application

Mitomycin C has been used:
  • to cease mitosis
  • in phosphate buffer saline (PBS) for inactivation and plating mouse embryonic fibroblasts (MEFs)
  • as mutagen in mutagenicity assay

Mitomycin C is used as an inhibitor for studies of cell-free protein biosynthesis. It also inhibits DNA synthesis. It has been used as a genotoxic agent for tumor cells.

Biochem/physiol Actions

Mitomycin C (MMC) acts as a prototype for drugs with bioreductive alkylation. It is mainly found to be active under anaerobic conditions. MMC exhibits a vast clinical antitumor spectrum effectively in gastric, pancreatic and breast cancer.

General description

Mitomycin C is an antitumor antibiotic.

Other Notes

For life science research only. Not for use in diagnostic procedures.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H300,H351

Hazard Classifications

Acute Tox. 2 Oral - Carc. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

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Certificates of Analysis (COA)

Lot/Batch Number
66178900
62669600
46983900
40496900
38475000

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Jeremy Setton et al.
NPJ breast cancer, 7(1), 135-135 (2021-10-13)
Pathogenic germline mutations in the RAD51 paralog genes RAD51C and RAD51D, are known to confer susceptibility to ovarian and triple-negative breast cancer. Here, we investigated whether germline loss-of-function variants affecting another RAD51 paralog gene, RAD51B, are also associated with breast
Preparation of mouse embryonic fibroblast cells suitable for culturing human embryonic and induced pluripotent stem cells
Jozefczuk J, et al.
Journal of Visualized Experiments, 130(64), e3854-e3854 (2012)
Microbial Mutagenicity Assay: Ames Test
Vijay U, et al.
Bio-protocol, e3854-e3854 (2018)
Renato B Baleeiro et al.
Oncoimmunology, 11(1), 2080329-2080329 (2022-06-04)
MHC class II expression is a hallmark of professional antigen-presenting cells and key to the induction of CD4+ T helper cells. We found that these molecules are ectopically expressed on tumor cells in a large proportion of patients with pancreatic
Sertoli cell-mediated differentiation of bovine fetal mesenchymal stem cells into germ cell lineage using an in vitro co-culture system
Segunda MN, et al.
Theriogenology, 130, 8-18 (2019)
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